Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease.
The extent of synchronization within and between the nuclei of the basal ganglia is unknown in Parkinson's disease. The question is an important one because synchronization will increase postsynaptic efficacy at subsequent projection targets. We simultaneously recorded local potentials (LPs) fr...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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| _version_ | 1797094487168647168 |
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| author | Brown, P Oliviero, A Mazzone, P Insola, A Tonali, P Di Lazzaro, V |
| author_facet | Brown, P Oliviero, A Mazzone, P Insola, A Tonali, P Di Lazzaro, V |
| author_sort | Brown, P |
| collection | OXFORD |
| description | The extent of synchronization within and between the nuclei of the basal ganglia is unknown in Parkinson's disease. The question is an important one because synchronization will increase postsynaptic efficacy at subsequent projection targets. We simultaneously recorded local potentials (LPs) from the globus pallidus interna (GPi) and subthalamic nucleus (STN) in four awake patients after neurosurgery for Parkinson's disease. Nuclei from both sides were recorded in two patients so that a total of six ipsilateral GPi-STN LP recordings were made. Without medication, the power within and the coherence between the GPi and STN was dominated by activity with a frequency <30 Hz. Treatment with the dopamine precursor levodopa reduced the low-frequency activity and resulted in a new peak at approximately 70 Hz. This was evident in the power spectrum from STN and GPi and in the coherence between these nuclei. The phase relationship between the nuclei varied in a complex manner according to frequency band and the presence of exogenous dopaminergic stimulation. Synchronization of activity does occur between pallidum and STN, and its pattern is critically dependent on the level of dopaminergic activity. |
| first_indexed | 2024-03-07T04:14:44Z |
| format | Journal article |
| id | oxford-uuid:c909eb5f-7faa-4bd9-88b0-13149d7bd6e9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:14:44Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:c909eb5f-7faa-4bd9-88b0-13149d7bd6e92022-03-27T06:56:13ZDopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c909eb5f-7faa-4bd9-88b0-13149d7bd6e9EnglishSymplectic Elements at Oxford2001Brown, POliviero, AMazzone, PInsola, ATonali, PDi Lazzaro, VThe extent of synchronization within and between the nuclei of the basal ganglia is unknown in Parkinson's disease. The question is an important one because synchronization will increase postsynaptic efficacy at subsequent projection targets. We simultaneously recorded local potentials (LPs) from the globus pallidus interna (GPi) and subthalamic nucleus (STN) in four awake patients after neurosurgery for Parkinson's disease. Nuclei from both sides were recorded in two patients so that a total of six ipsilateral GPi-STN LP recordings were made. Without medication, the power within and the coherence between the GPi and STN was dominated by activity with a frequency <30 Hz. Treatment with the dopamine precursor levodopa reduced the low-frequency activity and resulted in a new peak at approximately 70 Hz. This was evident in the power spectrum from STN and GPi and in the coherence between these nuclei. The phase relationship between the nuclei varied in a complex manner according to frequency band and the presence of exogenous dopaminergic stimulation. Synchronization of activity does occur between pallidum and STN, and its pattern is critically dependent on the level of dopaminergic activity. |
| spellingShingle | Brown, P Oliviero, A Mazzone, P Insola, A Tonali, P Di Lazzaro, V Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease. |
| title | Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease. |
| title_full | Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease. |
| title_fullStr | Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease. |
| title_full_unstemmed | Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease. |
| title_short | Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease. |
| title_sort | dopamine dependency of oscillations between subthalamic nucleus and pallidum in parkinson s disease |
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