Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5.

Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5.

Бусад хувилбаруудыг харуулах (1)

BACKGROUND AND AIMS: Adenomatous polyposis coli (APC) is a tumour suppressor gene mutated in the germline of patients with familial adenomatous polyposis (FAP) and somatically in most colorectal cancers. APC mutations impair β-catenin degradation, resulting in increased Wnt signalling. The most fre...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Lewis, A, Segditsas, S, Deheragoda, M, Pollard, P, Jeffery, R, Nye, E, Lockstone, H, Davis, H, Clark, S, Stamp, G, Poulsom, R, Wright, N, Tomlinson, I
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2010

Ижил төстэй зүйлс

Severe polyposis in Apc1322T mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5
-н: Lewis, A, зэрэг
Хэвлэсэн: (2010)

The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.
-н: Pollard, P, зэрэг
Хэвлэсэн: (2009)

The C-terminus of Apc does not influence intestinal adenoma development or progression
-н: Lewis, A, зэрэг
Хэвлэсэн: (2012)

The C-terminus of Apc does not influence intestinal adenoma development or progression.
-н: Lewis, A, зэрэг
Хэвлэсэн: (2012)

The APC1310T/+ mouse: A novel murine model of intestinal tumorigenesis analogous to the APC-1309 mutation causing severe intestinal polyposis in humans
-н: Deheragoda, MG, зэрэг
Хэвлэсэн: (2007)

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice.
-н: Segditsas, S, зэрэг
Хэвлэсэн: (2008)

The Apcl323t/+ mouse: A novel murine model analagous to the APC-1309 mutation causing severe intestinal polyposis in humans
-н: Deheragoda, MG, зэрэг
Хэвлэсэн: (2007)

The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.
-н: Sieber, O, зэрэг
Хэвлэсэн: (2000)

Germline epimutations of APC are not associated with inherited colorectal polyposis.
-н: Hitchins, M, зэрэг
Хэвлэсэн: (2006)

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.
-н: Segditsas, S, зэрэг
Хэвлэсэн: (2008)

Stem Cell Location Throughout the Human Gastrointestinal Tract as Defined by LGR5 mRNA In Situ Hybridisation
-н: McDonald, S, зэрэг
Хэвлэсэн: (2010)

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas
-н: Sieber, O, зэрэг
Хэвлэсэн: (2002)

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas.
-н: Sieber, O, зэрэг
Хэвлэсэн: (2002)

The fluctuation of APC gene in WNT signaling with adenine deletion of adenomatous polyposis coli, is associated in colorectal cancer
-н: Seyedeh Elham Norollahi, зэрэг
Хэвлэсэн: (2020-04-01)

The role of cell proliferation and crypt fission in adenoma aggressiveness: a comparison of ileoanal pouch and rectal adenomas in familial adenomatous polyposis.
-н: Will, O, зэрэг
Хэвлэсэн: (2011)

Adenomatous Polyposis Coli (APC) in cell migration
-н: Xingyuan Fang, зэрэг
Хэвлэсэн: (2022-06-01)

Colorectal cancer and genetic alterations in the Wnt pathway.
-н: Segditsas, S, зэрэг
Хэвлэсэн: (2006)

Familial adenomatous polyposis (FAP) and its gene, APC.
-н: Bodmer, W
Хэвлэсэн: (1999)

Complete deletion of Apc results in severe polyposis in mice
-н: Bronson, Roderick T., зэрэг
Хэвлэсэн: (2014)

APC and the three-hit hypothesis.
-н: Segditsas, S, зэрэг
Хэвлэсэн: (2009)

Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation.
-н: Sturt, N, зэрэг
Хэвлэсэн: (2004)

Wild-type APC Influences the Severity of Familial Adenomatous Polyposis
-н: Krzysztof Flisikowski, зэрэг
Хэвлэсэн: (2022-01-01)

Functional comparison of human Adenomatous Polyposis Coli (APC) and APC-like in targeting beta-catenin for degradation
-н: Schneikert, Jean, зэрэг
Хэвлэсэн: (2013)

Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation.
-н: Jean Schneikert, зэрэг
Хэвлэсэн: (2013-01-01)

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5.
-н: Heinz Ruffner, зэрэг
Хэвлэсэн: (2012-01-01)

Danish guidelines for management of non-APC-associated hereditary polyposis syndromes
-н: Anne Marie Jelsig, зэрэг
Хэвлэсэн: (2021-10-01)

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
-н: de Lau, W, зэрэг
Хэвлэсэн: (2011)

Wnt genes in colonic polyposis predisposition
-н: Isabel Quintana, зэрэг
Хэвлэсэн: (2023-05-01)

LGR5 is expressed by Ewing sarcoma and potentiates Wnt/β-catenin signaling
-н: Christopher A Scannell, зэрэг
Хэвлэсэн: (2013-04-01)

Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas.
-н: Cottrell, S, зэрэг
Хэвлэсэн: (1992)

Identification of an APC Variant in a Patient with Clinical Attenuated Familial Adenomatous Polyposis
-н: Andrew T. Schlussel, зэрэг
Хэвлэсэн: (2014-01-01)

Pathogenic <i>APC</i> Variants in Latvian Familial Adenomatous Polyposis Patients
-н: Zanda Daneberga, зэрэг
Хэвлэсэн: (2019-09-01)

Identification of mutation in 3'-end of exon 15 of APC gene in familial adenomatous polyposis patients
-н: Habibollahi H, зэрэг
Хэвлэсэн: (2020-02-01)

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis.
-н: Lamlum, H, зэрэг
Хэвлэсэн: (1999)

Lgr4 Regulates Oviductal Epithelial Secretion Through the WNT Signaling Pathway
-н: Xue Tan, зэрэг
Хэвлэсэн: (2021-09-01)

A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)
-н: Imelda T Sandoval, зэрэг
Хэвлэсэн: (2017-04-01)

Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells.
-н: Cesar A Sommer, зэрэг
Хэвлэсэн: (2018-01-01)

Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes
-н: Giovanna Forte, зэрэг
Хэвлэсэн: (2023-07-01)

T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations
-н: Céline Cuche, зэрэг
Хэвлэсэн: (2023-07-01)

Identification of a novel CNV at the APC gene in a Chinese family with familial adenomatous polyposis
-н: Juyi Li, зэрэг
Хэвлэсэн: (2023-07-01)