Allowing for non-adherence to treatment in a randomized controlled trial of two antidepressants (citalopram versus reboxetine): an example from the GENPOD trial.

BACKGROUND: Meta-analyses suggest that reboxetine may be less effective than other antidepressants. Such comparisons may be biased by lower adherence to reboxetine and subsequent handling of missing outcome data. This study illustrates how to adjust for differential non-adherence and hence derive an...

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Main Authors: Wiles, N, Fischer, K, Cowen, P, Nutt, D, Peters, T, Lewis, G, White, I
格式: Journal article
语言:English
出版: 2014