Analysis of the chronotropic effect of acetylcholine on sinoatrial node cells.

INTRODUCTION: The ionic basis underlying the negative chronotropic effect of acetylcholine (ACh) on sinoatrial (SA) node cells is unresolved and controversial. In the present study, mathematical modeling was used to address this issue. METHODS AND RESULTS: The known concentration-dependent effects...

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Main Authors: Zhang, H, Holden, A, Noble, D, Boyett, MR
格式: Journal article
语言:English
出版: 2002