Cobalt versus osmium: control of both trans and cis selectivity in construction of the EFG rings of pectenotoxin 4
Catalytic oxidative cyclisation reactions have been employed for the synthesis of the E and F rings of the complex natural product target pectenotoxin 4. The choice of metal catalyst (cobalt or osmium based) allowed for the formation of THF rings with either trans or cis stereoselectivity. Fragment...
| Autors principals: | , , , , , , , |
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| Format: | Journal article |
| Idioma: | English |
| Publicat: |
Wiley
2017
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| _version_ | 1826296373675294720 |
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| author | Roushanbakhti, A Liu, Y Winship, P Tucker, M Akhtar, W Walter, D Wrigley, G Donohoe, T |
| author_facet | Roushanbakhti, A Liu, Y Winship, P Tucker, M Akhtar, W Walter, D Wrigley, G Donohoe, T |
| author_sort | Roushanbakhti, A |
| collection | OXFORD |
| description | Catalytic oxidative cyclisation reactions have been employed for the synthesis of the E and F rings of the complex natural product target pectenotoxin 4. The choice of metal catalyst (cobalt or osmium based) allowed for the formation of THF rings with either trans or cis stereoselectivity. Fragment union using a modified Julia reaction then enabled the synthesis of an advanced synthetic intermediate containing the EF and G rings of the target. |
| first_indexed | 2024-03-07T04:15:20Z |
| format | Journal article |
| id | oxford-uuid:c9398b4b-2b23-46ed-8271-9300a6fc0246 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:15:20Z |
| publishDate | 2017 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:c9398b4b-2b23-46ed-8271-9300a6fc02462022-03-27T06:57:38ZCobalt versus osmium: control of both trans and cis selectivity in construction of the EFG rings of pectenotoxin 4Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c9398b4b-2b23-46ed-8271-9300a6fc0246EnglishSymplectic Elements at OxfordWiley2017Roushanbakhti, ALiu, YWinship, PTucker, MAkhtar, WWalter, DWrigley, GDonohoe, TCatalytic oxidative cyclisation reactions have been employed for the synthesis of the E and F rings of the complex natural product target pectenotoxin 4. The choice of metal catalyst (cobalt or osmium based) allowed for the formation of THF rings with either trans or cis stereoselectivity. Fragment union using a modified Julia reaction then enabled the synthesis of an advanced synthetic intermediate containing the EF and G rings of the target. |
| spellingShingle | Roushanbakhti, A Liu, Y Winship, P Tucker, M Akhtar, W Walter, D Wrigley, G Donohoe, T Cobalt versus osmium: control of both trans and cis selectivity in construction of the EFG rings of pectenotoxin 4 |
| title | Cobalt versus osmium: control of both trans and cis selectivity in construction of the EFG rings of pectenotoxin 4 |
| title_full | Cobalt versus osmium: control of both trans and cis selectivity in construction of the EFG rings of pectenotoxin 4 |
| title_fullStr | Cobalt versus osmium: control of both trans and cis selectivity in construction of the EFG rings of pectenotoxin 4 |
| title_full_unstemmed | Cobalt versus osmium: control of both trans and cis selectivity in construction of the EFG rings of pectenotoxin 4 |
| title_short | Cobalt versus osmium: control of both trans and cis selectivity in construction of the EFG rings of pectenotoxin 4 |
| title_sort | cobalt versus osmium control of both trans and cis selectivity in construction of the efg rings of pectenotoxin 4 |
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