Activation of mitogen activated Protein Kinases (MAPKs) and gene induction upon explantation in articular cartilage from wild type and FGF-2(-/-) mice

Eitemau Tebyg

• Induction of interleukin-1 in articular cartilage by explantation and cutting.
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• Articular cartilage injury rapidly activates TAK1 in chondrocytes by inducing its phosphorylation and K63-polyubiquitination
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• Detection of Mitogen-activated Protein Kinase (MAPK) Activation upon Exogenous Chemical Application in Arabidopsis Protoplasts
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• Sharp injury to articular cartilage activates JNK and NF kappa B and induces expression of inflammatory response genes
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• Basic FGF mediates an immediate response of articular cartilage to mechanical injury.
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