VEGF‐A inhibits agonist‐mediated Ca2+ responses and activation of IKCa channels in mouse resistance artery endothelial cells

VEGF‐A inhibits agonist‐mediated Ca2+ responses and activation of IKCa channels in mouse resistance artery endothelial cells

Vascular endothelial growth factor A (VEGF‐A) is a potent permeability and angiogenic factor that is also associated with the remodelling of the microvasculature. Elevated VEGF‐A levels are linked to a significant increase in the risk of cardiovascular dysfunction, although it is unclear how VEGF‐A...

Full description

Bibliographic Details
Main Authors:	Ye, X, Beckett, T, Bagher, P, Garland, C, Dora, K
Format:	Journal article
Published:	Wiley 2018

Similar Items

Differential roles for IKCa and SKCa channels in EDHF-type responses in mouse mesenteric arteries
by: Gallagher, N, et al.
Published: (2006)

Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone.
by: Bagher, P, et al.
Published: (2012)

1-ethyl-2-benzimidazolinone activates endothelial cell IKCa and smooth muscle hyperpolarization in rat isolated mesenteric artery
by: Walker, S, et al.
Published: (2002)

Evidence for involvement of both IKCa and SKCa channels in hyperpolarizing responses of the rat middle cerebral artery.
by: McNeish, A, et al.
Published: (2006)

β₁-Adrenoceptor stimulation suppresses endothelial IK(Ca)-channel hyperpolarization and associated dilatation in resistance arteries.
by: Yarova, P, et al.
Published: (2013)

Role of Ca2+-activated K+ channels in dilatation evoked by purinergic agonists and flow in rat small mesenteric arteries
by: Winter, P, et al.
Published: (2006)

A central role for endothelial cell potassium channels in EDHF-mediated responses
by: Dora, K, et al.
Published: (2001)

Measurement of changes in endothelial and smooth muscle Ca²⁺ in pressurized arteries.
by: Dora, K, et al.
Published: (2013)

K(Ca) channel blockers reveal hyperpolarization and relaxation to K+ in rat isolated mesenteric artery.
by: Dora, K, et al.
Published: (2002)

Enhanced spontaneous Ca2+ events in endothelial cells reflect signalling through myoendothelial gap junctions in pressurized mesenteric arteries.
by: Kansui, Y, et al.
Published: (2008)

Role of endothelial cell ion channels in the resistance artery function
by: Garland, C
Published: (2003)

TRPM4 inhibitor 9‐phenanthrol activates endothelial cell intermediate conductance calcium‐activated potassium channels in rat isolated mesenteric artery
by: Garland, C, et al.
Published: (2014)

Desensitization of the dilatation response mediated by endothelial P2Y receptors in pressurized rat small mesenteric artery
by: Rodriguez-Rodriguez, R, et al.
Published: (2008)

A novel approach for imaging calcium events simultaneously in arteriolar vascular smooth muscle and endothelial cells
by: Bagher, P, et al.
Published: (2012)

A novel approach for imaging calcium events simultaneously in arteriolar vascular smooth muscle and endothelial cells
by: Bagher, P, et al.
Published: (2010)

Ca2+-dependent K+-channels and endothelium dependent hyperpolarization in rat isolated cerebral arteries; Possible regulation by NO?
by: McNeish, A, et al.
Published: (2005)

Endothelial cell protein kinase G inhibits release of EDHF through a PKG-sensitive cation channel.
by: Dora, K, et al.
Published: (2001)

Activation of endothelial cell IK(Ca) with 1-ethyl-2-benzimidazolinone evokes smooth muscle hyperpolarization in rat isolated mesenteric artery.
by: Walker, S, et al.
Published: (2001)

Vascular hyperpolarization to β-adrenoceptor agonists evokes spreading dilatation in rat isolated mesenteric arteries.
by: Garland, C, et al.
Published: (2011)

Vascular hyperpolarization to β-adrenoceptor agonists evokes spreading dilatation in rat isolated mesenteric arteries.
by: Garland, C, et al.
Published: (2011)

Modulation of endothelial cell KCa3.1 channels during endothelium-derived hyperpolarizing factor signaling in mesenteric resistance arteries.
by: Dora, K, et al.
Published: (2008)

Evidence for relaxation to endothelium-derived hyperpolarizing factor (EDHF) in isolated small mesenteric arteries of the mouse
by: Dora, K, et al.
Published: (2001)

Inwardly rectifying potassium channels in rat hepatic artery endothelial and smooth muscle cells.
by: Walker, S, et al.
Published: (2000)

An Integrated Mathematical Model of Thrombin-, Histamine-and VEGF-Mediated Signalling in Endothelial Permeability
by: Wei, X. N., et al.
Published: (2011)

The involvement of intracellular Ca(2+) in 5-HT(1B/1D) receptor-mediated contraction of the rabbit isolated renal artery.
by: Hill, P, et al.
Published: (2000)

Lack of synergism between flow and ATP in stimulating increases in vascular endothelial cell [Ca2+]i
by: Spitaler, M, et al.
Published: (2006)

Spreading dilatation in rat mesenteric arteries associated with calcium-independent endothelial cell hyperpolarization.
by: Takano, H, et al.
Published: (2004)

Endothelial cell Ca2+ increases are independent of membrane potential in pressurized rat mesenteric arteries.
by: McSherry, I, et al.
Published: (2005)

Nerve-mediated responses in isolated myogenic and non-myogenic arteries
by: Lemmey, HAL, et al.
Published: (2019)

Voltage-dependent Ca2+ entry into smooth muscle during contraction promotes endothelium-mediated feedback vasodilation in arterioles
by: Garland, CJ, et al.
Published: (2017)

Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A
by: Faulkner, A, et al.
Published: (2020)

A novel role for spontaneous endothelial cell calcium activity in the vascular myogenic response
by: Bagher, P, et al.
Published: (2013)

Role of endothelial cell K+ channels in spreading dilatation
by: Dora, K, et al.
Published: (2004)

Regulation of CRAC channels and agonist-induced Ca2+ signals
by: Douglas, S
Published: (2012)

Intercellular Ca(2+) signalling: the artery wall
by: Dora, K
Published: (2001)

Intercellular Ca2+ signalling: the artery wall.
by: Dora, K
Published: (2001)

A mechanosensitive cation channel in endothelial cells and its role in vasoregulation.
by: Yao, X, et al.
Published: (2003)

Modulation of responses to exogenous potassium by potassium channel activity in the rat isolated mesenteric artery
by: Dora, K, et al.
Published: (2002)

Acetylcholine inhibits voltage-dependent Ca2+ channels in mouse pancreatic B-cells.
by: Gilon, P, et al.
Published: (1996)

Smooth muscle gap-junctions allow propagation of intercellular Ca2+ waves and vasoconstriction due to Ca2+ based action potentials in rat mesenteric resistance arteries
by: Borysova, L, et al.
Published: (2018)