Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection.

Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection.

The role of cytotoxic T-lymphocyte (CTL) escape in rapidly progressive infant human immunodeficiency virus type 1 (HIV-1) infection is undefined. The data presented here demonstrate that infant HIV-1-specific CTL can select for viral escape variants very early in life. These variants, furthermore, m...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Pillay, T, Zhang, H, Drijfhout, J, Robinson, N, Brown, H, Khan, M, Moodley, J, Adhikari, M, Pfafferott, K, Feeney, M, St John, A, Holmes, E, Coovadia, H, Klenerman, P, Goulder, P, Phillips, R
Format:	Journal article
Sprache:	English
Veröffentlicht:	2005

Ähnliche Einträge

Intrapatient escape in the A*0201-restricted epitope SLYNTVATL drives evolution of human immunodeficiency virus type 1 at the population level.
von: Edwards, C, et al.
Veröffentlicht: (2005)

Sexual transmission of single human immunodeficiency virus type 1 virions encoding highly polymorphic multisite cytotoxic T-lymphocyte escape variants.
von: Milicic, A, et al.
Veröffentlicht: (2005)

Cytotoxic T lymphocyte responses to human immunodeficiency virus: control and escape.
von: Sewell, A, et al.
Veröffentlicht: (2000)

Human immunodeficiency virus variants that escape cytotoxic T-cell recognition.
von: Rowland-Jones, S, et al.
Veröffentlicht: (1992)

Precise identification of a human immunodeficiency virus type 1 antigen processing mutant.
von: Zimbwa, P, et al.
Veröffentlicht: (2007)

HIV escape and attenuation by cytotoxic T lymphocytes.
von: Leslie, A, et al.
Veröffentlicht: (2006)

Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection.
von: Price, D, et al.
Veröffentlicht: (1997)

Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child.
von: Feeney, M, et al.
Veröffentlicht: (2004)

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition.
von: Phillips, R, et al.
Veröffentlicht: (1991)

Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.
von: Martinez-Picado, J, et al.
Veröffentlicht: (2006)

Co-evolution of human immunodeficiency virus and cytotoxic T-lymphocyte responses.
von: Goulder, P, et al.
Veröffentlicht: (1997)

Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.
von: Draenert, R, et al.
Veröffentlicht: (2004)

Passive sexual transmission of human immunodeficiency virus type 1 variants and adaptation in new hosts.
von: Frater, A, et al.
Veröffentlicht: (2006)

Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection.
von: Allen, T, et al.
Veröffentlicht: (2004)

Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
von: Frahm, N, et al.
Veröffentlicht: (2006)

Modelling the evolution and spread of HIV immune escape mutants.
von: Fryer, H, et al.
Veröffentlicht: (2010)

Cytotoxic T lymphocyte lysis inhibited by viable HIV mutants.
von: Meier, U, et al.
Veröffentlicht: (1995)

Escape of human immunodeficiency virus from immune control.
von: McMichael, A, et al.
Veröffentlicht: (1997)

Determinants of human immunodeficiency virus type 1 escape from the primary CD8+ cytotoxic T lymphocyte response.
von: Jones, N, et al.
Veröffentlicht: (2004)

Defective escape mutants of HIV.
von: Berry, R, et al.
Veröffentlicht: (1994)

Effective T-cell responses select human immunodeficiency virus mutants and slow disease progression.
von: Frater, A, et al.
Veröffentlicht: (2007)

The effects of natural altered peptide ligands on the whole blood cytotoxic T lymphocyte response to human immunodeficiency virus.
von: Klenerman, P, et al.
Veröffentlicht: (1995)

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS.
von: Goulder, P, et al.
Veröffentlicht: (1997)

Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays.
von: Goulder, P, et al.
Veröffentlicht: (2001)

Comprehensive screening reveals strong and broadly directed human immunodeficiency virus type 1-specific CD8 responses in perinatally infected children.
von: Feeney, M, et al.
Veröffentlicht: (2003)

Cytotoxic T lymphocytes and viral adaptation in HIV infection.
von: Goulder, P, et al.
Veröffentlicht: (2006)

Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.
von: Yu, X, et al.
Veröffentlicht: (2007)

Cytotoxic T-lymphocyte escape mutations identified by HLA association favor those which escape and revert rapidly.
von: Fryer, H, et al.
Veröffentlicht: (2012)

HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load.
von: Rousseau, C, et al.
Veröffentlicht: (2008)

How does the HIV escape cytotoxic T cell immunity?
von: Phillips, R, et al.
Veröffentlicht: (1993)

CYTOTOXIC T-LYMPHOCYTE RECOGNITION OF HIV - EPITOPE SELECTION AND ESCAPE
von: Mcmichael, A, et al.
Veröffentlicht: (1993)

HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.
von: Feeney, M, et al.
Veröffentlicht: (2005)

HIV escapes from cytoxic lymphocytes
von: McMichael, A, et al.
Veröffentlicht: (1996)

Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication.
von: Schneidewind, A, et al.
Veröffentlicht: (2007)

Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children.
von: Goulder, P, et al.
Veröffentlicht: (2000)

Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection.
von: Day, C, et al.
Veröffentlicht: (2007)

Impairment of CD4(+) T cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants.
von: Ciurea, A, et al.
Veröffentlicht: (2001)

Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities.
von: Frahm, N, et al.
Veröffentlicht: (2004)

Modelling the spread of HIV immune escape mutants in a vaccinated population
von: Fryer, H, et al.
Veröffentlicht: (2011)

Functional consequences of human immunodeficiency virus escape from an HLA-B*13-restricted CD8+ T-cell epitope in p1 Gag protein.
von: Prado, J, et al.
Veröffentlicht: (2009)