The presence of valine at residue 129 in human prion protein accelerates amyloid formation.

The presence of valine at residue 129 in human prion protein accelerates amyloid formation.

The polymorphism at residue 129 of the human PRNP gene modulates disease susceptibility and the clinico-pathological phenotypes in human transmissible spongiform encephalopathies. The molecular mechanisms by which the effect of this polymorphism are mediated remain unclear. It has been shown that th...

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Bibliographic Details
Main Authors:	Baskakov, I, Disterer, P, Breydo, L, Shaw, M, Gill, A, James, W, Tahiri-Alaoui, A
Format:	Journal article
Language:	English
Published:	2005

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