The evolution of gene expression levels in mammalian organs.
Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological limitations. Here we report the sequencing of polyadenylated RNA from six organs across ten...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2011
|
| _version_ | 1797094638977286144 |
|---|---|
| author | Brawand, D Soumillon, M Necsulea, A Julien, P Csárdi, G Harrigan, P Weier, M Liechti, A Aximu-Petri, A Kircher, M Albert, F Zeller, U Khaitovich, P Grützner, F Bergmann, S Nielsen, R Pääbo, S Kaessmann, H |
| author_facet | Brawand, D Soumillon, M Necsulea, A Julien, P Csárdi, G Harrigan, P Weier, M Liechti, A Aximu-Petri, A Kircher, M Albert, F Zeller, U Khaitovich, P Grützner, F Bergmann, S Nielsen, R Pääbo, S Kaessmann, H |
| author_sort | Brawand, D |
| collection | OXFORD |
| description | Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological limitations. Here we report the sequencing of polyadenylated RNA from six organs across ten species that represent all major mammalian lineages (placentals, marsupials and monotremes) and birds (the evolutionary outgroup), with the goal of understanding the dynamics of mammalian transcriptome evolution. We show that the rate of gene expression evolution varies among organs, lineages and chromosomes, owing to differences in selective pressures: transcriptome change was slow in nervous tissues and rapid in testes, slower in rodents than in apes and monotremes, and rapid for the X chromosome right after its formation. Although gene expression evolution in mammals was strongly shaped by purifying selection, we identify numerous potentially selectively driven expression switches, which occurred at different rates across lineages and tissues and which probably contributed to the specific organ biology of various mammals. |
| first_indexed | 2024-03-07T04:16:46Z |
| format | Journal article |
| id | oxford-uuid:c9aa1274-eff4-48e7-b4f8-6ecf153e45a1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:16:46Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:c9aa1274-eff4-48e7-b4f8-6ecf153e45a12022-03-27T07:01:08ZThe evolution of gene expression levels in mammalian organs.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c9aa1274-eff4-48e7-b4f8-6ecf153e45a1EnglishSymplectic Elements at Oxford2011Brawand, DSoumillon, MNecsulea, AJulien, PCsárdi, GHarrigan, PWeier, MLiechti, AAximu-Petri, AKircher, MAlbert, FZeller, UKhaitovich, PGrützner, FBergmann, SNielsen, RPääbo, SKaessmann, HChanges in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological limitations. Here we report the sequencing of polyadenylated RNA from six organs across ten species that represent all major mammalian lineages (placentals, marsupials and monotremes) and birds (the evolutionary outgroup), with the goal of understanding the dynamics of mammalian transcriptome evolution. We show that the rate of gene expression evolution varies among organs, lineages and chromosomes, owing to differences in selective pressures: transcriptome change was slow in nervous tissues and rapid in testes, slower in rodents than in apes and monotremes, and rapid for the X chromosome right after its formation. Although gene expression evolution in mammals was strongly shaped by purifying selection, we identify numerous potentially selectively driven expression switches, which occurred at different rates across lineages and tissues and which probably contributed to the specific organ biology of various mammals. |
| spellingShingle | Brawand, D Soumillon, M Necsulea, A Julien, P Csárdi, G Harrigan, P Weier, M Liechti, A Aximu-Petri, A Kircher, M Albert, F Zeller, U Khaitovich, P Grützner, F Bergmann, S Nielsen, R Pääbo, S Kaessmann, H The evolution of gene expression levels in mammalian organs. |
| title | The evolution of gene expression levels in mammalian organs. |
| title_full | The evolution of gene expression levels in mammalian organs. |
| title_fullStr | The evolution of gene expression levels in mammalian organs. |
| title_full_unstemmed | The evolution of gene expression levels in mammalian organs. |
| title_short | The evolution of gene expression levels in mammalian organs. |
| title_sort | evolution of gene expression levels in mammalian organs |
| work_keys_str_mv | AT brawandd theevolutionofgeneexpressionlevelsinmammalianorgans AT soumillonm theevolutionofgeneexpressionlevelsinmammalianorgans AT necsuleaa theevolutionofgeneexpressionlevelsinmammalianorgans AT julienp theevolutionofgeneexpressionlevelsinmammalianorgans AT csardig theevolutionofgeneexpressionlevelsinmammalianorgans AT harriganp theevolutionofgeneexpressionlevelsinmammalianorgans AT weierm theevolutionofgeneexpressionlevelsinmammalianorgans AT liechtia theevolutionofgeneexpressionlevelsinmammalianorgans AT aximupetria theevolutionofgeneexpressionlevelsinmammalianorgans AT kircherm theevolutionofgeneexpressionlevelsinmammalianorgans AT albertf theevolutionofgeneexpressionlevelsinmammalianorgans AT zelleru theevolutionofgeneexpressionlevelsinmammalianorgans AT khaitovichp theevolutionofgeneexpressionlevelsinmammalianorgans AT grutznerf theevolutionofgeneexpressionlevelsinmammalianorgans AT bergmanns theevolutionofgeneexpressionlevelsinmammalianorgans AT nielsenr theevolutionofgeneexpressionlevelsinmammalianorgans AT paabos theevolutionofgeneexpressionlevelsinmammalianorgans AT kaessmannh theevolutionofgeneexpressionlevelsinmammalianorgans AT brawandd evolutionofgeneexpressionlevelsinmammalianorgans AT soumillonm evolutionofgeneexpressionlevelsinmammalianorgans AT necsuleaa evolutionofgeneexpressionlevelsinmammalianorgans AT julienp evolutionofgeneexpressionlevelsinmammalianorgans AT csardig evolutionofgeneexpressionlevelsinmammalianorgans AT harriganp evolutionofgeneexpressionlevelsinmammalianorgans AT weierm evolutionofgeneexpressionlevelsinmammalianorgans AT liechtia evolutionofgeneexpressionlevelsinmammalianorgans AT aximupetria evolutionofgeneexpressionlevelsinmammalianorgans AT kircherm evolutionofgeneexpressionlevelsinmammalianorgans AT albertf evolutionofgeneexpressionlevelsinmammalianorgans AT zelleru evolutionofgeneexpressionlevelsinmammalianorgans AT khaitovichp evolutionofgeneexpressionlevelsinmammalianorgans AT grutznerf evolutionofgeneexpressionlevelsinmammalianorgans AT bergmanns evolutionofgeneexpressionlevelsinmammalianorgans AT nielsenr evolutionofgeneexpressionlevelsinmammalianorgans AT paabos evolutionofgeneexpressionlevelsinmammalianorgans AT kaessmannh evolutionofgeneexpressionlevelsinmammalianorgans |