Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.

Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.

We generated a transgenic mouse model expressing the apical hypertrophic cardiomyopathy-causing mutation ACTC E99K at 50% of total heart actin and compared it with actin from patients carrying the same mutation. The actin mutation caused a higher Ca(2+) sensitivity in reconstituted thin filaments me...

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Hlavní autoři: Song, W, Dyer, E, Stuckey, D, Copeland, O, Leung, M, Bayliss, C, Messer, A, Wilkinson, R, Tremoleda, J, Schneider, MD, Harding, SE, Redwood, C, Clarke, K, Nowak, K, Monserrat, L, Wells, D, Marston, S
Médium: Journal article
Jazyk:English
Vydáno: 2011

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