Molecular mechanisms of migraine?
Migraine is a common debilitating neurological disease characterised by attacks of severe headache with or without preceding aura. Its aetiology remains elusive; however it is clear that an interplay of genetic and environmental components play an important role. Familial hemiplegic migraine (FHM) i...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1826296484836933632 |
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| author | Ramagopalan, S Ramscar, N Cader, M |
| author_facet | Ramagopalan, S Ramscar, N Cader, M |
| author_sort | Ramagopalan, S |
| collection | OXFORD |
| description | Migraine is a common debilitating neurological disease characterised by attacks of severe headache with or without preceding aura. Its aetiology remains elusive; however it is clear that an interplay of genetic and environmental components play an important role. Familial hemiplegic migraine (FHM) is a rare and severe variant of migraine with aura and follows an autosomal dominant pattern of inheritance. This disease is genetically heterogeneous,with three causative genes having been identified. This review uses insights garnered from FHM to try and shed light on possible migraine disease pathogenesis. |
| first_indexed | 2024-03-07T04:17:03Z |
| format | Journal article |
| id | oxford-uuid:c9c0088f-3a5e-4ae0-a763-5f19ca53e99e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:17:03Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:c9c0088f-3a5e-4ae0-a763-5f19ca53e99e2022-03-27T07:01:47ZMolecular mechanisms of migraine?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c9c0088f-3a5e-4ae0-a763-5f19ca53e99eEnglishSymplectic Elements at Oxford2007Ramagopalan, SRamscar, NCader, MMigraine is a common debilitating neurological disease characterised by attacks of severe headache with or without preceding aura. Its aetiology remains elusive; however it is clear that an interplay of genetic and environmental components play an important role. Familial hemiplegic migraine (FHM) is a rare and severe variant of migraine with aura and follows an autosomal dominant pattern of inheritance. This disease is genetically heterogeneous,with three causative genes having been identified. This review uses insights garnered from FHM to try and shed light on possible migraine disease pathogenesis. |
| spellingShingle | Ramagopalan, S Ramscar, N Cader, M Molecular mechanisms of migraine? |
| title | Molecular mechanisms of migraine? |
| title_full | Molecular mechanisms of migraine? |
| title_fullStr | Molecular mechanisms of migraine? |
| title_full_unstemmed | Molecular mechanisms of migraine? |
| title_short | Molecular mechanisms of migraine? |
| title_sort | molecular mechanisms of migraine |
| work_keys_str_mv | AT ramagopalans molecularmechanismsofmigraine AT ramscarn molecularmechanismsofmigraine AT caderm molecularmechanismsofmigraine |