Home alone: a population neuroscience investigation of brain morphology substrates
As a social species, ready exchange with peers is a pivotal asset - our “social capital”. Yet, single-person households have come to pervade metropolitan cities worldwide, with unknown consequences in the long run. Here, we systematically explore the morphological manifestations associated with sing...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2023
|
| _version_ | 1826310239341772800 |
|---|---|
| author | Noonan, M Zajner, C Bzdok, D |
| author_facet | Noonan, M Zajner, C Bzdok, D |
| author_sort | Noonan, M |
| collection | OXFORD |
| description | As a social species, ready exchange with peers is a pivotal asset - our “social capital”. Yet, single-person households have come to pervade metropolitan cities worldwide, with unknown consequences in the long run. Here, we systematically explore the morphological manifestations associated with singular living in ∼40,000 UK Biobank participants. The uncovered population-level signature spotlights the highly associative default mode network, in addition to findings such as in the amygdala central, cortical and corticoamygdaloid nuclei groups, as well as the hippocampal fimbria and dentate gyrus. Both positive effects, equating to greater gray matter volume associated with living alone, and negative effects, which can be interpreted as greater gray matter associations with not living alone, were found across the cortex and subcortical structures Sex-stratified analyses revealed male-specific neural substrates, including somatomotor, saliency and visual systems, while female-specific neural substrates centered on the dorsomedial prefrontal cortex. In line with our demographic profiling results, the discovered neural pattern of living alone is potentially linked to alcohol and tobacco consumption, anxiety, sleep quality as well as daily TV watching. The persistent trend for solitary living will require new answers from public-health decision makers. |
| first_indexed | 2024-03-07T07:47:30Z |
| format | Journal article |
| id | oxford-uuid:c9c1dbee-2481-4e73-bb33-095a16394b6c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:47:30Z |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:c9c1dbee-2481-4e73-bb33-095a16394b6c2023-06-20T10:55:17ZHome alone: a population neuroscience investigation of brain morphology substratesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c9c1dbee-2481-4e73-bb33-095a16394b6cEnglishSymplectic ElementsElsevier2023Noonan, MZajner, CBzdok, DAs a social species, ready exchange with peers is a pivotal asset - our “social capital”. Yet, single-person households have come to pervade metropolitan cities worldwide, with unknown consequences in the long run. Here, we systematically explore the morphological manifestations associated with singular living in ∼40,000 UK Biobank participants. The uncovered population-level signature spotlights the highly associative default mode network, in addition to findings such as in the amygdala central, cortical and corticoamygdaloid nuclei groups, as well as the hippocampal fimbria and dentate gyrus. Both positive effects, equating to greater gray matter volume associated with living alone, and negative effects, which can be interpreted as greater gray matter associations with not living alone, were found across the cortex and subcortical structures Sex-stratified analyses revealed male-specific neural substrates, including somatomotor, saliency and visual systems, while female-specific neural substrates centered on the dorsomedial prefrontal cortex. In line with our demographic profiling results, the discovered neural pattern of living alone is potentially linked to alcohol and tobacco consumption, anxiety, sleep quality as well as daily TV watching. The persistent trend for solitary living will require new answers from public-health decision makers. |
| spellingShingle | Noonan, M Zajner, C Bzdok, D Home alone: a population neuroscience investigation of brain morphology substrates |
| title | Home alone: a population neuroscience investigation of brain morphology substrates |
| title_full | Home alone: a population neuroscience investigation of brain morphology substrates |
| title_fullStr | Home alone: a population neuroscience investigation of brain morphology substrates |
| title_full_unstemmed | Home alone: a population neuroscience investigation of brain morphology substrates |
| title_short | Home alone: a population neuroscience investigation of brain morphology substrates |
| title_sort | home alone a population neuroscience investigation of brain morphology substrates |
| work_keys_str_mv | AT noonanm homealoneapopulationneuroscienceinvestigationofbrainmorphologysubstrates AT zajnerc homealoneapopulationneuroscienceinvestigationofbrainmorphologysubstrates AT bzdokd homealoneapopulationneuroscienceinvestigationofbrainmorphologysubstrates |