Association between metabolic syndrome and risk of incident dementia in UK Biobank
<p><strong>INTRODUCTION:</strong> The association between metabolic syndrome (MetS) and incident dementia remains inconclusive.</p> <p><strong>METHODS:</strong> In 176,249 dementia-free UK Biobank participants aged ≥60 years at baseline, Cox proportional-ha...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2023
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| _version_ | 1826312488247885824 |
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| author | Qureshi, D Collister, J Allen, NE Kuźma, E Littlejohns, TJ |
| author_facet | Qureshi, D Collister, J Allen, NE Kuźma, E Littlejohns, TJ |
| author_sort | Qureshi, D |
| collection | OXFORD |
| description | <p><strong>INTRODUCTION:</strong> The association between metabolic syndrome (MetS) and incident dementia remains inconclusive.</p>
<p><strong>METHODS:</strong> In 176,249 dementia-free UK Biobank participants aged ≥60 years at baseline, Cox proportional-hazards models were used to investigate the association between MetS and incident dementia. MetS was defined as the presence of ≥3 of the following: elevated waist circumference, triglycerides, blood pressure, blood glucose, and reduced high-density lipoprotein cholesterol.</p>
<p><strong>RESULTS:</strong> Over 15 years of follow-up (median = 12.3), 5255 participants developed dementia. MetS was associated with an increased risk of incident dementia (hazard ratio [HR]: 1.12, 95% confidence interval [CI]: 1.06, 1.18). The association remained consistent when restricting to longer follow-up intervals: >5 to 10 years (HR: 1.17, 95% CI: 1.07, 1.27) and >10 years (HR: 1.22, 95% CI: 1.12, 1.32). Stronger associations were observed in those with ≥4 MetS components and in apolipoprotein-E (APOE)-ε4 non-carriers.</p>
<p><strong>DISCUSSION:</strong> In this large population-based prospective cohort, MetS was associated with an increased risk of dementia.<p>
Highlights
• MetS was associated with a 12% increased risk of incident all-cause dementia.
• Associations remained similar after restricting the analysis to those with longer follow-up.
• The presence of four or five MetS components was significantly associated with dementia.
• Stronger associations were observed in those with a low genetic risk for dementia. |
| first_indexed | 2024-03-07T07:59:32Z |
| format | Journal article |
| id | oxford-uuid:c9c91c03-aa90-44bc-a89c-5a7ce7211004 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-04-09T03:55:20Z |
| publishDate | 2023 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:c9c91c03-aa90-44bc-a89c-5a7ce72110042024-03-08T09:54:02ZAssociation between metabolic syndrome and risk of incident dementia in UK BiobankJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c9c91c03-aa90-44bc-a89c-5a7ce7211004EnglishSymplectic ElementsWiley2023Qureshi, DCollister, JAllen, NEKuźma, ELittlejohns, TJ<p><strong>INTRODUCTION:</strong> The association between metabolic syndrome (MetS) and incident dementia remains inconclusive.</p> <p><strong>METHODS:</strong> In 176,249 dementia-free UK Biobank participants aged ≥60 years at baseline, Cox proportional-hazards models were used to investigate the association between MetS and incident dementia. MetS was defined as the presence of ≥3 of the following: elevated waist circumference, triglycerides, blood pressure, blood glucose, and reduced high-density lipoprotein cholesterol.</p> <p><strong>RESULTS:</strong> Over 15 years of follow-up (median = 12.3), 5255 participants developed dementia. MetS was associated with an increased risk of incident dementia (hazard ratio [HR]: 1.12, 95% confidence interval [CI]: 1.06, 1.18). The association remained consistent when restricting to longer follow-up intervals: >5 to 10 years (HR: 1.17, 95% CI: 1.07, 1.27) and >10 years (HR: 1.22, 95% CI: 1.12, 1.32). Stronger associations were observed in those with ≥4 MetS components and in apolipoprotein-E (APOE)-ε4 non-carriers.</p> <p><strong>DISCUSSION:</strong> In this large population-based prospective cohort, MetS was associated with an increased risk of dementia.<p> Highlights • MetS was associated with a 12% increased risk of incident all-cause dementia. • Associations remained similar after restricting the analysis to those with longer follow-up. • The presence of four or five MetS components was significantly associated with dementia. • Stronger associations were observed in those with a low genetic risk for dementia. |
| spellingShingle | Qureshi, D Collister, J Allen, NE Kuźma, E Littlejohns, TJ Association between metabolic syndrome and risk of incident dementia in UK Biobank |
| title | Association between metabolic syndrome and risk of incident dementia in UK Biobank |
| title_full | Association between metabolic syndrome and risk of incident dementia in UK Biobank |
| title_fullStr | Association between metabolic syndrome and risk of incident dementia in UK Biobank |
| title_full_unstemmed | Association between metabolic syndrome and risk of incident dementia in UK Biobank |
| title_short | Association between metabolic syndrome and risk of incident dementia in UK Biobank |
| title_sort | association between metabolic syndrome and risk of incident dementia in uk biobank |
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