SPATA2 links CYLD to LUBAC, activates CYLD and controls LUBAC signaling

SPATA2 links CYLD to LUBAC, activates CYLD and controls LUBAC signaling

The Linear UBiquitin chain Assembly Complex (LUBAC) regulates immune signaling and its function is regulated by the deubiquitinases OTULIN and CYLD that associate with the catalytic subunit HOIP. However, the mechanism through which CYLD interacts with HOIP is unclear. We here show that CYLD interac...

Полное описание

Библиографические подробности
Главные авторы:	Elliott, P, Leske, D, Hrdinka, M, Bagola, K, Fiil, B, McLaughlin, S, Wagstaff, J, Volkmar, N, Christianson, J, Kessler, B, Freund, S, Komander, D, Gyrd-Hansen, M
Формат:	Journal article
Опубликовано:	Cell Press 2016

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