ATM and Chk2 kinase target the p53 cofactor Strap.

ATM and Chk2 kinase target the p53 cofactor Strap.

The p53 cofactor Strap (stress responsive activator of p300) is directly targeted by the DNA damage signalling pathway where phosphorylation by ATM (ataxia telangiectasia mutated) kinase facilitates nuclear accumulation. Here, we show that Strap regulation reflects the coordinated interplay between...

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Bibliographic Details
Main Authors: Adams, C, Graham, A, Jansson, M, Coutts, A, Edelmann, M, Smith, L, Kessler, B, La Thangue, N
Format: Journal article
Language:English
Published: 2008

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