Exploiting the defensive sugars of HIV-1 for drug and vaccine design

Exploiting the defensive sugars of HIV-1 for drug and vaccine design

The sustained effort towards developing an antibody vaccine against HIV/AIDS has provided much of our understanding of viral immunology. It is generally accepted that one of the main barriers to antibody neutralization of HIV is the array of protective structural carbohydrates that covers the antige...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Scanlan, C, Offer, J, Zitzmann, N, Dwek, R
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	Nature Research 2007

समान संसाधन

Emerging principles for the therapeutic exploitation of glycosylation.
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Sugar immunogens
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Antigenic mimicry of the HIV envelope by AIDS-Associated pathogens
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प्रकाशित: (2008)

Antigenic mimicry of the HIV envelope by AIDS-associated pathogens.
द्वारा: Dunlop, D, और अन्य
प्रकाशित: (2008)

Yeast mannan genetics controls the molecular specificity of anti-carbohydrate antibodies cross-reactive to the HIV envelope
द्वारा: Dunlop, D, और अन्य
प्रकाशित: (2009)

Glycobiology against viruses: Antiviral drug discovery
द्वारा: Zitzmann, N, और अन्य
प्रकाशित: (2006)

P05-11. Yeast mannan genetics controls the molecular specificity of anti-carbohydrate antibodies cross-reactive to the HIV envelope
द्वारा: Dwek R, और अन्य
प्रकाशित: (2009-10-01)

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द्वारा: Fleet, G, और अन्य
प्रकाशित: (1988)

N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery.
द्वारा: Pollock, S, और अन्य
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Liposome treatment of viral infections
द्वारा: Dwek, R, और अन्य
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Host-targeting oral antiviral drugs to prevent pandemics
द्वारा: Dwek, RA, और अन्य
प्रकाशित: (2022)

Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.
द्वारा: Scanlan, C, और अन्य
प्रकाशित: (2007)

Clinical diagnosis of hepatic fibrosis using human serum APOL1 as biomarker
द्वारा: Gangadharan, B, और अन्य
प्रकाशित: (2012)

Imino sugar therapy for type 1 Gaucher disease.
द्वारा: Priestman, D, और अन्य
प्रकाशित: (2000)

Exploiting B Cell Receptor Analyses to Inform on HIV-1 Vaccination Strategies
द्वारा: Christoph Kreer, और अन्य
प्रकाशित: (2020-01-01)

Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells.
द्वारा: Pollock, S, और अन्य
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Use of iminosugar derivatives to inhibit ion channel activity
द्वारा: Zitzmann, N, और अन्य
प्रकाशित: (2004)

Molecular mechanisms for enhancing the antigenicity of the carbohydrate epitope of the broadly neutralizing anti-HIV-1 antibody 2G12
द्वारा: Fulton, Z, और अन्य
प्रकाशित: (2009)

Defensive Driving: Directing HIV-1 Vaccine-Induced Humoral Immunity to the Mucosa with Chemokine Adjuvants
द्वारा: Ebony N. Gary, और अन्य
प्रकाशित: (2018-01-01)

Endoplasmic reticulum targeting liposomes
द्वारा: Pollock, S, और अन्य
प्रकाशित: (2011)

Cholesterol level lowering liposomes
द्वारा: Pollock, S, और अन्य
प्रकाशित: (2012)

Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses.
द्वारा: Butters, T, और अन्य
प्रकाशित: (2005)

Sugar and enzymes: Exploring and exploiting protein-carbohydrate interactions
द्वारा: Davis, B
प्रकाशित: (2006)

Sugars and enzymes: Exploring and exploiting protein-carbohydrate interactions.
द्वारा: Davis, B
प्रकाशित: (2005)

Sugars and enzymes: Exploring and exploiting protein-carbohydrate interactions
द्वारा: Davis, B
प्रकाशित: (2005)

A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.
द्वारा: Doores, K, और अन्य
प्रकाशित: (2010)

The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein
द्वारा: Whitfield, T, और अन्य
प्रकाशित: (2011)

Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: Implications for the development of broad spectrum anti-hepatitis virus agents
द्वारा: Zitzmann, N, और अन्य
प्रकाशित: (1999)

Therapeutic applications of imino sugars in lysosomal storage disorders.
द्वारा: Butters, T, और अन्य
प्रकाशित: (2003)

Hardware-assisted online defense against malware and exploits
द्वारा: Das, Sanjeev Kumar
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Exploiting viral properties for the rational design of modern vaccines.
द्वारा: Spohn, G, और अन्य
प्रकाशित: (2008)

Proteomics in uveal melanoma research: opportunities and challenges in biomarker discovery.
द्वारा: Pardo, M, और अन्य
प्रकाशित: (2007)

Clinical diagnosis of hepatic fibrosis using a novel panel of low abundant human plasma protein biomarkers
द्वारा: Gangadharan, B, और अन्य
प्रकाशित: (2010)

Clinical diagnosis of hepatic fibrosis using a novel panel of human serum protein biomarkers
द्वारा: Gangadharan, B, और अन्य
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Exploitation of Unconventional CD8 T-Cell Responses Induced by Engineered Cytomegaloviruses for the Development of an HIV-1 Vaccine
द्वारा: Joseph Bruton, और अन्य
प्रकाशित: (2025-01-01)

The Case for Exploiting Cross-Species Epitopes in Malaria Vaccine Design
द्वारा: Catherine J. Mitran, और अन्य
प्रकाशित: (2020-02-01)

The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12.
द्वारा: Scanlan, C, और अन्य
प्रकाशित: (2003)

Sugar-mediated ligand-receptor interactions in the immune system.
द्वारा: Rudd, P, और अन्य
प्रकाशित: (2004)

The silent defense: Micro-RNA directed defense against HIV-1 replication
द्वारा: Kumar Ajit
प्रकाशित: (2007-04-01)

Exploitation of Documented Historical Floods for Achieving Better Flood Defense
द्वारा: Slobodan Kolaković, और अन्य
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