Exploiting the defensive sugars of HIV-1 for drug and vaccine design

Exploiting the defensive sugars of HIV-1 for drug and vaccine design

The sustained effort towards developing an antibody vaccine against HIV/AIDS has provided much of our understanding of viral immunology. It is generally accepted that one of the main barriers to antibody neutralization of HIV is the array of protective structural carbohydrates that covers the antige...

Полное описание

Библиографические подробности
Главные авторы:	Scanlan, C, Offer, J, Zitzmann, N, Dwek, R
Формат:	Journal article
Язык:	English
Опубликовано:	Nature Research 2007

Схожие документы

Emerging principles for the therapeutic exploitation of glycosylation.
по: Dalziel, M, и др.
Опубликовано: (2014)

Sugar immunogens
по: Dwek, R, и др.
Опубликовано: (2009)

Antigenic mimicry of the HIV envelope by AIDS-Associated pathogens
по: Dunlop, D, и др.
Опубликовано: (2008)

Antigenic mimicry of the HIV envelope by AIDS-associated pathogens.
по: Dunlop, D, и др.
Опубликовано: (2008)

Yeast mannan genetics controls the molecular specificity of anti-carbohydrate antibodies cross-reactive to the HIV envelope
по: Dunlop, D, и др.
Опубликовано: (2009)

Glycobiology against viruses: Antiviral drug discovery
по: Zitzmann, N, и др.
Опубликовано: (2006)

P05-11. Yeast mannan genetics controls the molecular specificity of anti-carbohydrate antibodies cross-reactive to the HIV envelope
по: Dwek R, и др.
Опубликовано: (2009-10-01)

Inhibition of HIV replication by amino-sugar derivatives.
по: Fleet, G, и др.
Опубликовано: (1988)

N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery.
по: Pollock, S, и др.
Опубликовано: (2008)

Liposome treatment of viral infections
по: Dwek, R, и др.
Опубликовано: (2011)

Host-targeting oral antiviral drugs to prevent pandemics
по: Dwek, RA, и др.
Опубликовано: (2022)

Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.
по: Scanlan, C, и др.
Опубликовано: (2007)

Clinical diagnosis of hepatic fibrosis using human serum APOL1 as biomarker
по: Gangadharan, B, и др.
Опубликовано: (2012)

Imino sugar therapy for type 1 Gaucher disease.
по: Priestman, D, и др.
Опубликовано: (2000)

Exploiting B Cell Receptor Analyses to Inform on HIV-1 Vaccination Strategies
по: Christoph Kreer, и др.
Опубликовано: (2020-01-01)

Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells.
по: Pollock, S, и др.
Опубликовано: (2010)

Use of iminosugar derivatives to inhibit ion channel activity
по: Zitzmann, N, и др.
Опубликовано: (2004)

Molecular mechanisms for enhancing the antigenicity of the carbohydrate epitope of the broadly neutralizing anti-HIV-1 antibody 2G12
по: Fulton, Z, и др.
Опубликовано: (2009)

Defensive Driving: Directing HIV-1 Vaccine-Induced Humoral Immunity to the Mucosa with Chemokine Adjuvants
по: Ebony N. Gary, и др.
Опубликовано: (2018-01-01)

Endoplasmic reticulum targeting liposomes
по: Pollock, S, и др.
Опубликовано: (2011)

Cholesterol level lowering liposomes
по: Pollock, S, и др.
Опубликовано: (2012)

Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses.
по: Butters, T, и др.
Опубликовано: (2005)

Sugar and enzymes: Exploring and exploiting protein-carbohydrate interactions
по: Davis, B
Опубликовано: (2006)

Sugars and enzymes: Exploring and exploiting protein-carbohydrate interactions.
по: Davis, B
Опубликовано: (2005)

Sugars and enzymes: Exploring and exploiting protein-carbohydrate interactions
по: Davis, B
Опубликовано: (2005)

A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.
по: Doores, K, и др.
Опубликовано: (2010)

The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein
по: Whitfield, T, и др.
Опубликовано: (2011)

Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: Implications for the development of broad spectrum anti-hepatitis virus agents
по: Zitzmann, N, и др.
Опубликовано: (1999)

Therapeutic applications of imino sugars in lysosomal storage disorders.
по: Butters, T, и др.
Опубликовано: (2003)

Hardware-assisted online defense against malware and exploits
по: Das, Sanjeev Kumar
Опубликовано: (2016)

Exploiting viral properties for the rational design of modern vaccines.
по: Spohn, G, и др.
Опубликовано: (2008)

Proteomics in uveal melanoma research: opportunities and challenges in biomarker discovery.
по: Pardo, M, и др.
Опубликовано: (2007)

Clinical diagnosis of hepatic fibrosis using a novel panel of low abundant human plasma protein biomarkers
по: Gangadharan, B, и др.
Опубликовано: (2010)

Clinical diagnosis of hepatic fibrosis using a novel panel of human serum protein biomarkers
по: Gangadharan, B, и др.
Опубликовано: (2008)

Exploitation of Unconventional CD8 T-Cell Responses Induced by Engineered Cytomegaloviruses for the Development of an HIV-1 Vaccine
по: Joseph Bruton, и др.
Опубликовано: (2025-01-01)

The Case for Exploiting Cross-Species Epitopes in Malaria Vaccine Design
по: Catherine J. Mitran, и др.
Опубликовано: (2020-02-01)

The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12.
по: Scanlan, C, и др.
Опубликовано: (2003)

Sugar-mediated ligand-receptor interactions in the immune system.
по: Rudd, P, и др.
Опубликовано: (2004)

The silent defense: Micro-RNA directed defense against HIV-1 replication
по: Kumar Ajit
Опубликовано: (2007-04-01)

Exploitation of Documented Historical Floods for Achieving Better Flood Defense
по: Slobodan Kolaković, и др.
Опубликовано: (2016-01-01)