Association of age with 10-year outcomes after coronary surgery in the Arterial Revascularization Trial
<p><strong>Background</strong></p> <p>The association of age with the outcomes of bilateral internal thoracic arteries (BITAs) versus single internal thoracic arteries (SITAs) for coronary bypass grafting (CABG) remains to be determined.</p> <p><strong&g...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2021
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| _version_ | 1826296543847645184 |
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| author | Gaudino, M Di Franco, A Flather, M Gerry, S Bagiella, E Gray, A Pearcey, L Saw, TH Lees, B Benedetto, U Fremes, SE Taggart, DP |
| author_facet | Gaudino, M Di Franco, A Flather, M Gerry, S Bagiella, E Gray, A Pearcey, L Saw, TH Lees, B Benedetto, U Fremes, SE Taggart, DP |
| author_sort | Gaudino, M |
| collection | OXFORD |
| description | <p><strong>Background</strong></p>
<p>The association of age with the outcomes of bilateral internal thoracic arteries (BITAs) versus single internal thoracic arteries (SITAs) for coronary bypass grafting (CABG) remains to be determined.</p>
<p><strong>Objectives</strong></p>
<p>The purpose of this study was to evaluate the association between age and BITA versus SITA outcomes in the Arterial Revascularization Trial.</p>
<p><strong>Methods</strong></p>
<p>The primary endpoints were all-cause mortality and a composite of major adverse events, including all-cause mortality, myocardial infarction, or stroke. Secondary endpoints were bleeding complications and sternal wound complications up to 6 months after surgery. Multivariable fractional polynomials analysis and log-rank tests were used.</p>
<p><strong>Results</strong></p>
<p>Age did not affect any of the explored outcomes in the overall BITA versus SITA comparison in the intention-to-treat analysis and in the analysis based on the number of arterial grafts received. However, when the intention-to-treat analysis was restricted to the populations of patients between age 50 and 70 years, younger patients in the BITA arm had a significantly lower incidence of major adverse events (p = 0.03).</p>
<p><strong>Conclusions</strong></p>
<p>Our results suggest that BITA may improve long-term outcome in younger patients, although more randomized data are needed to confirm this hypothesis.</p> |
| first_indexed | 2024-03-07T04:17:58Z |
| format | Journal article |
| id | oxford-uuid:ca0972eb-59de-4220-935f-1630a505f3d6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:17:58Z |
| publishDate | 2021 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:ca0972eb-59de-4220-935f-1630a505f3d62022-03-27T07:04:33ZAssociation of age with 10-year outcomes after coronary surgery in the Arterial Revascularization TrialJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ca0972eb-59de-4220-935f-1630a505f3d6EnglishSymplectic ElementsElsevier2021Gaudino, MDi Franco, AFlather, MGerry, SBagiella, EGray, APearcey, LSaw, THLees, BBenedetto, UFremes, SETaggart, DP<p><strong>Background</strong></p> <p>The association of age with the outcomes of bilateral internal thoracic arteries (BITAs) versus single internal thoracic arteries (SITAs) for coronary bypass grafting (CABG) remains to be determined.</p> <p><strong>Objectives</strong></p> <p>The purpose of this study was to evaluate the association between age and BITA versus SITA outcomes in the Arterial Revascularization Trial.</p> <p><strong>Methods</strong></p> <p>The primary endpoints were all-cause mortality and a composite of major adverse events, including all-cause mortality, myocardial infarction, or stroke. Secondary endpoints were bleeding complications and sternal wound complications up to 6 months after surgery. Multivariable fractional polynomials analysis and log-rank tests were used.</p> <p><strong>Results</strong></p> <p>Age did not affect any of the explored outcomes in the overall BITA versus SITA comparison in the intention-to-treat analysis and in the analysis based on the number of arterial grafts received. However, when the intention-to-treat analysis was restricted to the populations of patients between age 50 and 70 years, younger patients in the BITA arm had a significantly lower incidence of major adverse events (p = 0.03).</p> <p><strong>Conclusions</strong></p> <p>Our results suggest that BITA may improve long-term outcome in younger patients, although more randomized data are needed to confirm this hypothesis.</p> |
| spellingShingle | Gaudino, M Di Franco, A Flather, M Gerry, S Bagiella, E Gray, A Pearcey, L Saw, TH Lees, B Benedetto, U Fremes, SE Taggart, DP Association of age with 10-year outcomes after coronary surgery in the Arterial Revascularization Trial |
| title | Association of age with 10-year outcomes after coronary surgery in the Arterial Revascularization Trial |
| title_full | Association of age with 10-year outcomes after coronary surgery in the Arterial Revascularization Trial |
| title_fullStr | Association of age with 10-year outcomes after coronary surgery in the Arterial Revascularization Trial |
| title_full_unstemmed | Association of age with 10-year outcomes after coronary surgery in the Arterial Revascularization Trial |
| title_short | Association of age with 10-year outcomes after coronary surgery in the Arterial Revascularization Trial |
| title_sort | association of age with 10 year outcomes after coronary surgery in the arterial revascularization trial |
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