Modulation of myocardial creatine transporter levels and the effects of gene regulation and post-translational modification on its function

Modulation of myocardial creatine transporter levels and the effects of gene regulation and post-translational modification on its function

<p>Heart failure (HF) is a common, disabling and deadly condition that causes high rates of morbidity and mortality worldwide. It is widely recognised that the failing heart is energy-starved, and that restoring energy homeostasis is a promising approach towards improving cardiac output. This...

Bibliografski detalji
Glavni autor:	Sebag-Montefiore, L
Daljnji autori:	Neubauer, S
Format:	Disertacija
Jezik:	English
Izdano:	2012
Teme:	Cardiovascular disease

Slični predmeti

Regulation of Myocardial Creatine Uptake by Intra- and Extracellular Creatine Levels
od: Makinen, K, i dr.
Izdano: (2008)

Regulation of myocardial creatine uptake capacity in genetically altered mouse models
od: Ten Hove, M, i dr.
Izdano: (2007)

Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.
od: Lygate, C, i dr.
Izdano: (2012)

The creatine kinase energy transport system in the failing mouse heart
od: Lygate, C, i dr.
Izdano: (2006)

Myocardial creatine uptake is regulated by the sarcolemmal fraction of the creatine transporter, but not by the total creatine transporter pool
od: Boehm, E, i dr.
Izdano: (2002)

Creatine uptake in mouse hearts with genetically altered creatine levels.
od: ten Hove, M, i dr.
Izdano: (2008)

The creatine kinase energy transport system in the failing mouse heart.
od: Lygate, C, i dr.
Izdano: (2007)

Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice.
od: Wallis, J, i dr.
Izdano: (2005)

Supernormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure - Insights from creatine transporter over-expression transgenic mice
od: Wallis, J, i dr.
Izdano: (2005)

Changes in creatine transporter function during cardiac maturation in the rat.
od: Fischer, A, i dr.
Izdano: (2010)

Supra-normal (phospho-)creatine levels lead to heart failure in mice overexpressing the cardiac creatine transporter - a longitudinal study
od: ten Hove, M, i dr.
Izdano: (2006)

Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity.
od: Phillips, D, i dr.
Izdano: (2010)

Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice
od: Lygate, C, i dr.
Izdano: (2013)

Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.
od: Lygate, C, i dr.
Izdano: (2013)

Targeted modulation of cardiac energetics via the creatine kinase system
od: Ostrowski, F
Izdano: (2013)

REGULATION OF CELLULAR CREATINE HOMEOSTASIS: A ROLE FOR THIOREDOXIN INTERACTING PROTEIN (TXNIP)
od: Zervou, S, i dr.
Izdano: (2013)

Elevated Myocardial Creatine Protects Against Ischemia/Reperfusion Injury by Improving Cardiac Energetics
od: Lygate, C, i dr.
Izdano: (2011)

Complete absence of creatine but unaltered ATP levels in hearts from AGAT knockout mice
od: ten Hove, M, i dr.
Izdano: (2007)

Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseases
od: Chunlu Jing, i dr.
Izdano: (2025-01-01)

The Role of Peroxisome Proliferator-Activated Receptor Gamma and Atherosclerosis: Post-translational Modification and Selective Modulators
od: Liqin Yin, i dr.
Izdano: (2022-03-01)

Changes of creatine kinase gene expression in rat heart post-myocardial infarction.
od: Neubauer, S, i dr.
Izdano: (1998)

Post-translational modifications of pyruvate dehydrogenase complex in cardiovascular disease
od: Bo Guo, i dr.
Izdano: (2024-09-01)

A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis.
od: Zervou, S, i dr.
Izdano: (2013)

Manipulating creatine levels post-myocardial infarction--chronic effects on left ventricular remodeling.
od: Neubauer, S, i dr.
Izdano: (1998)

Regulation and modulation of the creatine kinase system
od: Cao, F
Izdano: (2018)

Creatine transport and its regulation in skeletal and smooth muscle
od: Steele, S
Izdano: (1995)

Role of post-translational modifications of Sp1 in cardiovascular diseases
od: Xutao Sun, i dr.
Izdano: (2024-08-01)

The Regulation and Expression of the Creatine Transporter: A Brief Review of Creatine Supplementation in Humans and Animals
od: Greenwood Mike, i dr.
Izdano: (2006-06-01)

Creatine Kinase and Mortality in Peritoneal Dialysis
od: Xianfeng Wu, i dr.
Izdano: (2022-05-01)

Ribose supplementation alone or with elevated creatine does not preserve high energy nucleotides or cardiac function in the failing mouse heart
od: Faller, K, i dr.
Izdano: (2013)

Post-translational Modification Crosstalk and Hotspots in Sirtuin Interactors Implicated in Cardiovascular Diseases
od: Suruchi Aggarwal, i dr.
Izdano: (2020-04-01)

Tubulin Post-translational Modifications: Potential Therapeutic Approaches to Heart Failure
od: Chang Liu, i dr.
Izdano: (2022-04-01)

New creatine transporter assay and identification of distinct creatine transporter isoforms in muscle.
od: Walzel, B, i dr.
Izdano: (2002)

Adaptations to Maintain Energy Homeostasis Compensate for Creatine-Deficiency in GAMT Knockout Mice Following Myocardial Infarction, but May Contribute to Early Mitochondrial Pathology During Aging
od: Lygate, C, i dr.
Izdano: (2011)

Antiarrhythmic action of creatine in acute myocardial
od: Ana Iris López Medina, i dr.
Izdano: (2012-10-01)

Changes of creatine phosphokinase MB levels in the context of myocardial reperfusion injury
od: V. V. Semenyuta, i dr.
Izdano: (2022-11-01)

Regulation of Viral Restriction by Post-Translational Modifications
od: Célia Chamontin, i dr.
Izdano: (2021-11-01)

Regulation of insulin secretion by the post-translational modifications
od: Chunhua Yang, i dr.
Izdano: (2023-08-01)

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age
od: Lygate, C, i dr.
Izdano: (2012)

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age.
od: Lygate, C, i dr.
Izdano: (2012)