The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal sys...
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| Hlavní autoři: |
Galione, A,
Evans, A,
Ma, J,
Parrington, J,
Arredouani, A,
Cheng, X,
Zhu, M |
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| Médium: | Journal article
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| Jazyk: | English |
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| Vydáno: |
2009
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