The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal sys...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1797094741372829696 |
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| author | Galione, A Evans, A Ma, J Parrington, J Arredouani, A Cheng, X Zhu, M |
| author_facet | Galione, A Evans, A Ma, J Parrington, J Arredouani, A Cheng, X Zhu, M |
| author_sort | Galione, A |
| collection | OXFORD |
| description | In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal system highlights a new function for these organelles as targets for NAADP-mediated Ca(2+) mobilisation. In addition, we describe how TPCs may also trigger further Ca(2+) release by coupling to the endoplasmic reticular stores through activation of IP(3) receptors and ryanodine receptors. |
| first_indexed | 2024-03-07T04:18:12Z |
| format | Journal article |
| id | oxford-uuid:ca1cb4c8-c393-4448-aac5-d5bf3f659d2e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:18:12Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:ca1cb4c8-c393-4448-aac5-d5bf3f659d2e2022-03-27T07:05:01ZThe acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ca1cb4c8-c393-4448-aac5-d5bf3f659d2eEnglishSymplectic Elements at Oxford2009Galione, AEvans, AMa, JParrington, JArredouani, ACheng, XZhu, MIn this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal system highlights a new function for these organelles as targets for NAADP-mediated Ca(2+) mobilisation. In addition, we describe how TPCs may also trigger further Ca(2+) release by coupling to the endoplasmic reticular stores through activation of IP(3) receptors and ryanodine receptors. |
| spellingShingle | Galione, A Evans, A Ma, J Parrington, J Arredouani, A Cheng, X Zhu, M The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels. |
| title | The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels. |
| title_full | The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels. |
| title_fullStr | The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels. |
| title_full_unstemmed | The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels. |
| title_short | The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels. |
| title_sort | acid test the discovery of two pore channels tpcs as naadp gated endolysosomal ca 2 release channels |
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