The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.

The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.

In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal sys...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Galione, A, Evans, A, Ma, J, Parrington, J, Arredouani, A, Cheng, X, Zhu, M
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2009

Antzeko izenburuak

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The luminal Ca(2+) chelator, TPEN, inhibits NAADP-induced Ca(2+) release.
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NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing.
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Coordination of Ca2+ signalling by NAADP.
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The role of two pore channels (TPCs) in pancreatic beta cell stimulus-secretion coupling
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NAADP and cADPR signalling in sea urchin eggs
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Two-pore channels form homo- and heterodimers.
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Ca(2+) release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos
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Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release.
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NAADP-mediated channel 'chatter' in neurons of the rat medulla oblongata.
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Mechanism of action and functional role of the two-pore channels (TPCs) in key vertebrate physiological processes
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NAADP receptors.
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NAADP Receptors
nork: Galione, A
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NAADP receptors
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Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease.
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NAADP-induced calcium release in sea urchin eggs.
nork: Galione, A, et al.
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The endolysosomal cation channel TPC regulates social behavior by controlling oxytocin secretion
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Chemical synthesis of the novel Ca2+ messenger NAADP.
nork: Dowden, J, et al.
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