The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.

The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.

In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal sys...

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Príomhchruthaitheoirí:	Galione, A, Evans, A, Ma, J, Parrington, J, Arredouani, A, Cheng, X, Zhu, M
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	2009

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