Common and rare variants in multifactorial susceptibility to common diseases.

Common and rare variants in multifactorial susceptibility to common diseases.

Here, we give a historical overview of the search for genetic variants that influence the susceptibility of an individual to a chronic disease, from RA Fisher's seminal work to the current excitement of whole-genome association studies (WGAS). We then discuss the concepts behind the identificat...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Bodmer, W, Bonilla, C
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2008

Eitemau Tebyg

Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model.
gan: Fearnhead, N, et al.
Cyhoeddwyd: (2005)

A common mtDNA variant may be a susceptibility factor in 3 multifactorial diseases.
gan: Poulton, J, et al.
Cyhoeddwyd: (2001)

Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.
gan: Fearnhead, N, et al.
Cyhoeddwyd: (2004)

Rare copy-number variants as modulators of common disease susceptibility
gan: Chiara Auwerx, et al.
Cyhoeddwyd: (2024-01-01)

Genetic susceptibility to multifactorial diseases.
gan: Hill, A
Cyhoeddwyd: (1997)

Common disease, multiple rare (and distant) variants.
gan: Richard Robinson
Cyhoeddwyd: (2010-01-01)

The HLA system and the analysis of multifactorial genetic disease.
gan: Tomlinson, I, et al.
Cyhoeddwyd: (1995)

Association of common genetic variant with susceptibility to invasive pneumococcal disease
gan: Roy, S, et al.
Cyhoeddwyd: (2002)

Identification of rare and common variants in BNIP3L: a schizophrenia susceptibility gene
gan: Juan Zhou, et al.
Cyhoeddwyd: (2020-05-01)

Common or rare variants for complex traits?
gan: Munafò, MR, et al.
Cyhoeddwyd: (2014)

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates
gan: Jae Hoon Sul, et al.
Cyhoeddwyd: (2020-02-01)

The impact of rare and low-frequency genetic variants in common disease
gan: Lorenzo Bomba, et al.
Cyhoeddwyd: (2017-04-01)

Probability of Alzheimer’s disease based on common and rare genetic variants
gan: Valentina Escott-Price, et al.
Cyhoeddwyd: (2021-08-01)

Common disease: are causative alleles common or rare?
gan: Robert Shields
Cyhoeddwyd: (2011-01-01)

Investigating rare genetic variants in common migraine
gan: Weir, G
Cyhoeddwyd: (2014)

A Rare Variant of a Common Nodule
gan: Nancy Xi, et al.
Cyhoeddwyd: (2020-08-01)

Research pointers: Association of common genetic variant with susceptibility to invasive pneumococcal disease.
gan: Roy, S, et al.
Cyhoeddwyd: (2002)

Correction to: Probability of Alzheimer’s disease based on common and rare genetic variants
gan: Valentina Escott-Price, et al.
Cyhoeddwyd: (2021-09-01)

The 'common disease-common variant' hypothesis and familial risks.
gan: Kari Hemminki, et al.
Cyhoeddwyd: (2008-01-01)

Common variants at 11p13 are associated with susceptibility to tuberculosis.
gan: Thye, T, et al.
Cyhoeddwyd: (2012)

Common variants at 11p13 are associated with susceptibility to tuberculosis
gan: Thye, T, et al.
Cyhoeddwyd: (2012)

Common Genetic Variants in Rare Disorders: Hematology and Beyond
gan: Paschalis Evangelidis, et al.
Cyhoeddwyd: (2025-01-01)

Examining the role of common and rare mitochondrial variants in schizophrenia.
gan: Vanessa F Gonçalves, et al.
Cyhoeddwyd: (2018-01-01)

Common variants at 19p13 are associated with susceptibility to ovarian cancer.
gan: Bolton, K, et al.
Cyhoeddwyd: (2010)

Genetic susceptibility to common mycobacterial diseases
gan: Wong, H
Cyhoeddwyd: (2010)

Susceptibility of Clinical Enterobacterales Isolates With Common and Rare Carbapenemases to Mecillinam
gan: Frieder Fuchs, et al.
Cyhoeddwyd: (2021-01-01)

Clear Cell Myeloma - A Rare Histopathological Variant of a Common Disease
gan: Neha Agarwal, et al.
Cyhoeddwyd: (2024-01-01)

Discovery of common and rare genetic risk variants for colorectal cancer
gan: Huyghe, JR, et al.
Cyhoeddwyd: (2018)

Common sequence variants affect molecular function more than rare variants?
gan: Yannick Mahlich, et al.
Cyhoeddwyd: (2017-05-01)

Differential confounding of rare and common variants in spatially structured populations
gan: Mathieson, I, et al.
Cyhoeddwyd: (2012)

Differential confounding of rare and common variants in spatially structured populations.
gan: Mathieson, I, et al.
Cyhoeddwyd: (2012)

Spectrum of Rare and Common Genetic Variants in Arrhythmogenic Cardiomyopathy Patients
gan: Melania Lippi, et al.
Cyhoeddwyd: (2022-07-01)

Rare and common variants analysis of the EMB gene in patients with schizophrenia
gan: Juan Zhou, et al.
Cyhoeddwyd: (2020-03-01)

On genetic variants underlying common disease
gan: Hechter, E
Cyhoeddwyd: (2011)

Hirschsprung disease: common and uncommon variants
gan: Lily S Cheng, et al.
Cyhoeddwyd: (2024-08-01)

A robust GWSS method to simultaneously detect rare and common variants for complex disease.
gan: Chung-Feng Kao, et al.
Cyhoeddwyd: (2015-01-01)

Common variants in the CYP2C19 gene are associated with susceptibility to endometriosis
gan: Painter, J, et al.
Cyhoeddwyd: (2014)

Common variants in the CYP2C19 gene are associated with susceptibility to endometriosis.
gan: Painter, J, et al.
Cyhoeddwyd: (2014)

Common risk variants for epilepsy are enriched in families previously targeted for rare monogenic variant discovery
gan: Karen L. Oliver, et al.
Cyhoeddwyd: (2022-07-01)

Targeted sequencing identifies novel variants in common and rare MODY genes
gan: Lucas S. deSantana, et al.
Cyhoeddwyd: (2019-12-01)