Clinical and virological features of Dengue in Vietnamese infants
BACKGROUND: Infants account for a small proportion of the overall dengue case burden in endemic countries but can be clinically more difficult to manage. The clinical and laboratory features in infants with dengue have not been extensively characterised. METHODOLOGY/PRINCIPAL FINDINGS: This prospec...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Public Library of Science
2010
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| _version_ | 1826296599156883456 |
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| author | Chau, TN Anders, KL Lien, LB Hung, NT Hieu, LT Tuan, NM Thuy, TT Phuong, LT Tham, NT Lanh, MN Farrar, JJ Whitehead, SS Simmons, CP |
| author_facet | Chau, TN Anders, KL Lien, LB Hung, NT Hieu, LT Tuan, NM Thuy, TT Phuong, LT Tham, NT Lanh, MN Farrar, JJ Whitehead, SS Simmons, CP |
| author_sort | Chau, TN |
| collection | OXFORD |
| description | BACKGROUND: Infants account for a small proportion of the overall dengue case burden in endemic countries but can be clinically more difficult to manage. The clinical and laboratory features in infants with dengue have not been extensively characterised. METHODOLOGY/PRINCIPAL FINDINGS: This prospective, cross-sectional descriptive study of infants hospitalized with dengue was conducted in Vietnam from November 2004 to December 2007. More than two-thirds of 303 infants enrolled on clinical suspicion of dengue had a serologically confirmed dengue virus (DENV) infection. Almost all were primary dengue infections and 80% of the infants developed DHF/DSS. At the time of presentation and during hospitalization, the clinical signs and symptoms in infants with dengue were difficult to distinguish from those with other febrile illnesses, suggesting that in infants early laboratory confirmation could assist appropriate management. Detection of plasma NS1 antigen was found to be a sensitive marker of acute dengue in infants with primary infection, especially in the first few days of illness. CONCLUSIONS/SIGNIFICANCE: Collectively, these results provide a systematic description of the clinical features of dengue in infants and highlight the value of NS1 detection for diagnosis. |
| first_indexed | 2024-03-07T04:18:50Z |
| format | Journal article |
| id | oxford-uuid:ca53678d-2f1d-422b-bdc1-9ddebd75612f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:18:50Z |
| publishDate | 2010 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:ca53678d-2f1d-422b-bdc1-9ddebd75612f2022-03-27T07:06:34ZClinical and virological features of Dengue in Vietnamese infantsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ca53678d-2f1d-422b-bdc1-9ddebd75612fEnglishSymplectic Elements at OxfordPublic Library of Science2010Chau, TNAnders, KLLien, LBHung, NTHieu, LTTuan, NMThuy, TTPhuong, LTTham, NTLanh, MNFarrar, JJWhitehead, SSSimmons, CP BACKGROUND: Infants account for a small proportion of the overall dengue case burden in endemic countries but can be clinically more difficult to manage. The clinical and laboratory features in infants with dengue have not been extensively characterised. METHODOLOGY/PRINCIPAL FINDINGS: This prospective, cross-sectional descriptive study of infants hospitalized with dengue was conducted in Vietnam from November 2004 to December 2007. More than two-thirds of 303 infants enrolled on clinical suspicion of dengue had a serologically confirmed dengue virus (DENV) infection. Almost all were primary dengue infections and 80% of the infants developed DHF/DSS. At the time of presentation and during hospitalization, the clinical signs and symptoms in infants with dengue were difficult to distinguish from those with other febrile illnesses, suggesting that in infants early laboratory confirmation could assist appropriate management. Detection of plasma NS1 antigen was found to be a sensitive marker of acute dengue in infants with primary infection, especially in the first few days of illness. CONCLUSIONS/SIGNIFICANCE: Collectively, these results provide a systematic description of the clinical features of dengue in infants and highlight the value of NS1 detection for diagnosis. |
| spellingShingle | Chau, TN Anders, KL Lien, LB Hung, NT Hieu, LT Tuan, NM Thuy, TT Phuong, LT Tham, NT Lanh, MN Farrar, JJ Whitehead, SS Simmons, CP Clinical and virological features of Dengue in Vietnamese infants |
| title | Clinical and virological features of Dengue in Vietnamese infants |
| title_full | Clinical and virological features of Dengue in Vietnamese infants |
| title_fullStr | Clinical and virological features of Dengue in Vietnamese infants |
| title_full_unstemmed | Clinical and virological features of Dengue in Vietnamese infants |
| title_short | Clinical and virological features of Dengue in Vietnamese infants |
| title_sort | clinical and virological features of dengue in vietnamese infants |
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