Interventions targeting glucocorticoid-Krüppel-like factor 15-branched-chain amino acid signaling improve disease phenotypes in spinal muscular atrophy mice
The circadian glucocorticoid-Krüppel-like factor 15-branched-chain amino acid (GC-KLF15-BCAA) signaling pathway is a key regulatory axis in muscle, whose imbalance has wide-reaching effects on metabolic homeostasis. Spinal muscular atrophy (SMA) is a neuromuscular disorder also characterized by intr...
Main Authors: | Walter, L, Deguise, M, Meijboom, K, Betts, C, Ahlskog, N, Van Westering, T, Hazell, g, McFall, E, Kordala, A, Hammond, S, Abendroth, F, Murray, L, Shorrock, H, Prosdocimo, D, Haldar, S, Jain, M, Gillingwater, T, Claus, P, Kothary, R, Wood, M, Bowerman, M |
---|---|
Format: | Journal article |
Language: | English |
Published: |
Elsevier
2018
|
Similar Items
-
Light modulation ameliorates expression of circadian genes and disease progression in spinal muscular atrophy mice
by: Walter, L, et al.
Published: (2018) -
Combining multiomics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy
by: Meijboom, KE, et al.
Published: (2021) -
Metabolic Dysfunction in Spinal Muscular Atrophy
by: Marc-Olivier Deguise, et al.
Published: (2021-05-01) -
Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy
by: Shabanpoor, F, et al.
Published: (2017) -
Profile of circadianly regulated metabolic genes in dystrophic heart
by: Betts, C, et al.
Published: (2018)