Harnessing the properties of dendritic cells in the pursuit of immunological tolerance
The acquisition of self-perpetuating, immunological tolerance specific for graft alloantigens has long been described as the “holy grail” of clinical transplantation. By removing the need for life-long immunosuppression following engraftment, the adverse consequences of immunosuppressive regimens, i...
| Main Authors: | , , |
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| Format: | Journal article |
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Elsevier
2017
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| _version_ | 1797094843116158976 |
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| author | Horton, C Shanmugarajah, K Fairchild, P |
| author_facet | Horton, C Shanmugarajah, K Fairchild, P |
| author_sort | Horton, C |
| collection | OXFORD |
| description | The acquisition of self-perpetuating, immunological tolerance specific for graft alloantigens has long been described as the “holy grail” of clinical transplantation. By removing the need for life-long immunosuppression following engraftment, the adverse consequences of immunosuppressive regimens, including chronic infections and malignancy, may be avoided. Furthermore, autoimmune diseases and allergy are, by definition, driven by aberrant immunological responses to ordinarily innocuous antigens. The re-establishment of permanent tolerance towards instigating antigens may, therefore, provide a cure to these common diseases. Whilst various cell types exhibiting a tolerogenic phenotype have been proposed for such a task, tolerogenic dendritic cells (tol-DCs) are exquisitely adapted for antigen presentation and interact with many facets of the immune system: as such, they are attractive candidates for use in strategies for immune intervention. We review here our current understanding of tol-DC mediated induction and maintenance of immunological tolerance. Additionally, we discuss recent in vitro findings from animal models and clinical trials of tol-DC immunotherapy in the setting of transplantation, autoimmunity and allergy which highlight their promising therapeutic potential, and speculate how tol-DC therapy may be developed in the future. |
| first_indexed | 2024-03-07T04:19:36Z |
| format | Journal article |
| id | oxford-uuid:ca8fea17-bfb7-4039-92d9-d8dbfca0d8e8 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T04:19:36Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:ca8fea17-bfb7-4039-92d9-d8dbfca0d8e82022-03-27T07:08:21ZHarnessing the properties of dendritic cells in the pursuit of immunological toleranceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ca8fea17-bfb7-4039-92d9-d8dbfca0d8e8Symplectic Elements at OxfordElsevier2017Horton, CShanmugarajah, KFairchild, PThe acquisition of self-perpetuating, immunological tolerance specific for graft alloantigens has long been described as the “holy grail” of clinical transplantation. By removing the need for life-long immunosuppression following engraftment, the adverse consequences of immunosuppressive regimens, including chronic infections and malignancy, may be avoided. Furthermore, autoimmune diseases and allergy are, by definition, driven by aberrant immunological responses to ordinarily innocuous antigens. The re-establishment of permanent tolerance towards instigating antigens may, therefore, provide a cure to these common diseases. Whilst various cell types exhibiting a tolerogenic phenotype have been proposed for such a task, tolerogenic dendritic cells (tol-DCs) are exquisitely adapted for antigen presentation and interact with many facets of the immune system: as such, they are attractive candidates for use in strategies for immune intervention. We review here our current understanding of tol-DC mediated induction and maintenance of immunological tolerance. Additionally, we discuss recent in vitro findings from animal models and clinical trials of tol-DC immunotherapy in the setting of transplantation, autoimmunity and allergy which highlight their promising therapeutic potential, and speculate how tol-DC therapy may be developed in the future. |
| spellingShingle | Horton, C Shanmugarajah, K Fairchild, P Harnessing the properties of dendritic cells in the pursuit of immunological tolerance |
| title | Harnessing the properties of dendritic cells in the pursuit of immunological tolerance |
| title_full | Harnessing the properties of dendritic cells in the pursuit of immunological tolerance |
| title_fullStr | Harnessing the properties of dendritic cells in the pursuit of immunological tolerance |
| title_full_unstemmed | Harnessing the properties of dendritic cells in the pursuit of immunological tolerance |
| title_short | Harnessing the properties of dendritic cells in the pursuit of immunological tolerance |
| title_sort | harnessing the properties of dendritic cells in the pursuit of immunological tolerance |
| work_keys_str_mv | AT hortonc harnessingthepropertiesofdendriticcellsinthepursuitofimmunologicaltolerance AT shanmugarajahk harnessingthepropertiesofdendriticcellsinthepursuitofimmunologicaltolerance AT fairchildp harnessingthepropertiesofdendriticcellsinthepursuitofimmunologicaltolerance |