A first-generation linkage disequilibrium map of human chromosome 22.
DNA sequence variants in specific genes or regions of the human genome are responsible for a variety of phenotypes such as disease risk or variable drug response. These variants can be investigated directly, or through their non-random associations with neighbouring markers (called linkage disequili...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2002
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| _version_ | 1826296658222120960 |
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| author | Dawson, E Abecasis, G Bumpstead, S Chen, Y Hunt, S Beare, D Pabial, J Dibling, T Tinsley, E Kirby, S Carter, D Papaspyridonos, M Livingstone, S Ganske, R Lõhmussaar, E Zernant, J Tõnisson, N Remm, M Mägi, R Puurand, T Vilo, J Kurg, A Rice, K Deloukas, P Mott, R |
| author_facet | Dawson, E Abecasis, G Bumpstead, S Chen, Y Hunt, S Beare, D Pabial, J Dibling, T Tinsley, E Kirby, S Carter, D Papaspyridonos, M Livingstone, S Ganske, R Lõhmussaar, E Zernant, J Tõnisson, N Remm, M Mägi, R Puurand, T Vilo, J Kurg, A Rice, K Deloukas, P Mott, R |
| author_sort | Dawson, E |
| collection | OXFORD |
| description | DNA sequence variants in specific genes or regions of the human genome are responsible for a variety of phenotypes such as disease risk or variable drug response. These variants can be investigated directly, or through their non-random associations with neighbouring markers (called linkage disequilibrium (LD)). Here we report measurement of LD along the complete sequence of human chromosome 22. Duplicate genotyping and analysis of 1,504 markers in Centre d'Etude du Polymorphisme Humain (CEPH) reference families at a median spacing of 15 kilobases (kb) reveals a highly variable pattern of LD along the chromosome, in which extensive regions of nearly complete LD up to 804 kb in length are interspersed with regions of little or no detectable LD. The LD patterns are replicated in a panel of unrelated UK Caucasians. There is a strong correlation between high LD and low recombination frequency in the extant genetic map, suggesting that historical and contemporary recombination rates are similar. This study demonstrates the feasibility of developing genome-wide maps of LD. |
| first_indexed | 2024-03-07T04:19:43Z |
| format | Journal article |
| id | oxford-uuid:ca9c0ceb-c3bf-4892-ac59-9c5896981ec9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:19:43Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:ca9c0ceb-c3bf-4892-ac59-9c5896981ec92022-03-27T07:08:42ZA first-generation linkage disequilibrium map of human chromosome 22.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ca9c0ceb-c3bf-4892-ac59-9c5896981ec9EnglishSymplectic Elements at Oxford2002Dawson, EAbecasis, GBumpstead, SChen, YHunt, SBeare, DPabial, JDibling, TTinsley, EKirby, SCarter, DPapaspyridonos, MLivingstone, SGanske, RLõhmussaar, EZernant, JTõnisson, NRemm, MMägi, RPuurand, TVilo, JKurg, ARice, KDeloukas, PMott, RDNA sequence variants in specific genes or regions of the human genome are responsible for a variety of phenotypes such as disease risk or variable drug response. These variants can be investigated directly, or through their non-random associations with neighbouring markers (called linkage disequilibrium (LD)). Here we report measurement of LD along the complete sequence of human chromosome 22. Duplicate genotyping and analysis of 1,504 markers in Centre d'Etude du Polymorphisme Humain (CEPH) reference families at a median spacing of 15 kilobases (kb) reveals a highly variable pattern of LD along the chromosome, in which extensive regions of nearly complete LD up to 804 kb in length are interspersed with regions of little or no detectable LD. The LD patterns are replicated in a panel of unrelated UK Caucasians. There is a strong correlation between high LD and low recombination frequency in the extant genetic map, suggesting that historical and contemporary recombination rates are similar. This study demonstrates the feasibility of developing genome-wide maps of LD. |
| spellingShingle | Dawson, E Abecasis, G Bumpstead, S Chen, Y Hunt, S Beare, D Pabial, J Dibling, T Tinsley, E Kirby, S Carter, D Papaspyridonos, M Livingstone, S Ganske, R Lõhmussaar, E Zernant, J Tõnisson, N Remm, M Mägi, R Puurand, T Vilo, J Kurg, A Rice, K Deloukas, P Mott, R A first-generation linkage disequilibrium map of human chromosome 22. |
| title | A first-generation linkage disequilibrium map of human chromosome 22. |
| title_full | A first-generation linkage disequilibrium map of human chromosome 22. |
| title_fullStr | A first-generation linkage disequilibrium map of human chromosome 22. |
| title_full_unstemmed | A first-generation linkage disequilibrium map of human chromosome 22. |
| title_short | A first-generation linkage disequilibrium map of human chromosome 22. |
| title_sort | first generation linkage disequilibrium map of human chromosome 22 |
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