Targeting the water network in cyclin G-associated kinase (GAK) with 4-anilino-quin(az)oline inhibitors
Water networks within kinase inhibitor design and more widely within drug discovery are generally poorly understood. The successful targeting of these networks prospectively has great promise for all facets of inhibitor design, including potency and selectivity for the target. Herein, we describe th...
| Main Authors: | , , , , , , , |
|---|---|
| 格式: | Journal article |
| 語言: | English |
| 出版: |
Wiley
2020
|