Multi-loop model of Alzheimer disease: an integrated perspective on the Wnt/GSK3β, α-Synuclein, and type 3 diabetes hypotheses
As the prevalence of Alzheimer disease (AD) continues to rise unabated, new models have been put forth to improve our understanding of this devastating condition. Although individual models may have their merits, integrated models may prove more valuable. Indeed, the reliable failures of monotherapi...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Frontiers Media
2019
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| _version_ | 1826296666461831168 |
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| author | Norwitz, NG Mota, AS Norwitz, SG Clarke, K |
| author_facet | Norwitz, NG Mota, AS Norwitz, SG Clarke, K |
| author_sort | Norwitz, NG |
| collection | OXFORD |
| description | As the prevalence of Alzheimer disease (AD) continues to rise unabated, new models have been put forth to improve our understanding of this devastating condition. Although individual models may have their merits, integrated models may prove more valuable. Indeed, the reliable failures of monotherapies for AD, and the ensuing surrender of major drug companies, suggests that an integrated perspective may be necessary if we are to invent multifaceted treatments that could ultimately prove more successful. In this review article, we discuss the Wnt/Glycogen Synthase Kinase 3β (GSK3β), α-synuclein, and type 3 diabetes hypotheses of AD, and their deep interconnection, in order to foster the integrative thinking that may be required to reach a solution for the coming neurological epidemic. |
| first_indexed | 2024-03-07T04:19:51Z |
| format | Journal article |
| id | oxford-uuid:caa9af9b-19ce-4c41-af2a-10ce59d9db68 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:19:51Z |
| publishDate | 2019 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:caa9af9b-19ce-4c41-af2a-10ce59d9db682022-03-27T07:08:56ZMulti-loop model of Alzheimer disease: an integrated perspective on the Wnt/GSK3β, α-Synuclein, and type 3 diabetes hypothesesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:caa9af9b-19ce-4c41-af2a-10ce59d9db68EnglishSymplectic ElementsFrontiers Media2019Norwitz, NGMota, ASNorwitz, SGClarke, KAs the prevalence of Alzheimer disease (AD) continues to rise unabated, new models have been put forth to improve our understanding of this devastating condition. Although individual models may have their merits, integrated models may prove more valuable. Indeed, the reliable failures of monotherapies for AD, and the ensuing surrender of major drug companies, suggests that an integrated perspective may be necessary if we are to invent multifaceted treatments that could ultimately prove more successful. In this review article, we discuss the Wnt/Glycogen Synthase Kinase 3β (GSK3β), α-synuclein, and type 3 diabetes hypotheses of AD, and their deep interconnection, in order to foster the integrative thinking that may be required to reach a solution for the coming neurological epidemic. |
| spellingShingle | Norwitz, NG Mota, AS Norwitz, SG Clarke, K Multi-loop model of Alzheimer disease: an integrated perspective on the Wnt/GSK3β, α-Synuclein, and type 3 diabetes hypotheses |
| title | Multi-loop model of Alzheimer disease: an integrated perspective on the Wnt/GSK3β, α-Synuclein, and type 3 diabetes hypotheses |
| title_full | Multi-loop model of Alzheimer disease: an integrated perspective on the Wnt/GSK3β, α-Synuclein, and type 3 diabetes hypotheses |
| title_fullStr | Multi-loop model of Alzheimer disease: an integrated perspective on the Wnt/GSK3β, α-Synuclein, and type 3 diabetes hypotheses |
| title_full_unstemmed | Multi-loop model of Alzheimer disease: an integrated perspective on the Wnt/GSK3β, α-Synuclein, and type 3 diabetes hypotheses |
| title_short | Multi-loop model of Alzheimer disease: an integrated perspective on the Wnt/GSK3β, α-Synuclein, and type 3 diabetes hypotheses |
| title_sort | multi loop model of alzheimer disease an integrated perspective on the wnt gsk3β α synuclein and type 3 diabetes hypotheses |
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