Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.
Extensive molecular studies have characterized 15 dimorphic and 2 multiallelic genetic markers within the human alpha-globin gene cluster. Analysis of these markers in 9 populations has shown that the alpha-globin locus is remarkably polymorphic and is therefore an ideal marker on chromosome 16 for...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1986
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| _version_ | 1797094903044374528 |
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| author | Higgs, D Wainscoat, J Flint, J Hill, A Thein, S Nicholls, R Teal, H Ayyub, H Peto, T Falusi, A |
| author_facet | Higgs, D Wainscoat, J Flint, J Hill, A Thein, S Nicholls, R Teal, H Ayyub, H Peto, T Falusi, A |
| author_sort | Higgs, D |
| collection | OXFORD |
| description | Extensive molecular studies have characterized 15 dimorphic and 2 multiallelic genetic markers within the human alpha-globin gene cluster. Analysis of these markers in 9 populations has shown that the alpha-globin locus is remarkably polymorphic and is therefore an ideal marker on chromosome 16 for the construction of a human genetic linkage map. The combined analysis of 9 polymorphic markers has established alpha-globin haplotypes that provide the means to study the molecular genetics and common mutants of this cluster. The novel association of a conventional restriction fragment length polymorphism haplotype and linked, hypervariable regions of DNA should allow a comparison of the rate of change of such markers. |
| first_indexed | 2024-03-07T04:20:20Z |
| format | Journal article |
| id | oxford-uuid:caccc292-61e8-4cd2-81ce-7761be02832f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:20:20Z |
| publishDate | 1986 |
| record_format | dspace |
| spelling | oxford-uuid:caccc292-61e8-4cd2-81ce-7761be02832f2022-03-27T07:10:02ZAnalysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:caccc292-61e8-4cd2-81ce-7761be02832fEnglishSymplectic Elements at Oxford1986Higgs, DWainscoat, JFlint, JHill, AThein, SNicholls, RTeal, HAyyub, HPeto, TFalusi, AExtensive molecular studies have characterized 15 dimorphic and 2 multiallelic genetic markers within the human alpha-globin gene cluster. Analysis of these markers in 9 populations has shown that the alpha-globin locus is remarkably polymorphic and is therefore an ideal marker on chromosome 16 for the construction of a human genetic linkage map. The combined analysis of 9 polymorphic markers has established alpha-globin haplotypes that provide the means to study the molecular genetics and common mutants of this cluster. The novel association of a conventional restriction fragment length polymorphism haplotype and linked, hypervariable regions of DNA should allow a comparison of the rate of change of such markers. |
| spellingShingle | Higgs, D Wainscoat, J Flint, J Hill, A Thein, S Nicholls, R Teal, H Ayyub, H Peto, T Falusi, A Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus. |
| title | Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus. |
| title_full | Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus. |
| title_fullStr | Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus. |
| title_full_unstemmed | Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus. |
| title_short | Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus. |
| title_sort | analysis of the human alpha globin gene cluster reveals a highly informative genetic locus |
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