Effects of azithromycin in severe eosinophilic asthma with concomitant monoclonal antibody treatment
<p>Macrolides reduce exacerbations when added to inhaled therapy in severe asthma. However, there is little published evidence for effectiveness in patients treated with biologics. We conducted a retrospective audit of all patients who started azithromycin while on biologics in our centre. Com...
| Principais autores: | , , , , , , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
BMJ Publishing Group
2024
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| _version_ | 1826317032873787392 |
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| author | Lavoie, G Howell, I Melhorn, J Borg, C Bermejo-Sanchez, L Seymour, J Jabeen, MF Fries, A Hynes, G Pavord, ID Hinks, TSC Petousi, N |
| author_facet | Lavoie, G Howell, I Melhorn, J Borg, C Bermejo-Sanchez, L Seymour, J Jabeen, MF Fries, A Hynes, G Pavord, ID Hinks, TSC Petousi, N |
| author_sort | Lavoie, G |
| collection | OXFORD |
| description | <p>Macrolides reduce exacerbations when added to inhaled therapy in severe asthma. However, there is little published evidence for effectiveness in patients treated with biologics. We conducted a retrospective audit of all patients who started azithromycin while on biologics in our centre. Compared to those that did not start azithromycin, these individuals had more exacerbations and a phenotype of chronic bronchitis and/or frequent purulent exacerbations. Azithromycin added-on to biologics reduced the annual rate of steroid-treated and antibiotic-treated exacerbations, improved symptom scores (ACQ5) but did not change lung function. This suggests azithromycin may be an effective treatment in patients on biologics with residual exacerbations.</p> |
| first_indexed | 2024-12-09T03:23:00Z |
| format | Journal article |
| id | oxford-uuid:caff57a2-cc51-4cb9-b37c-cdf86002245e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-02-19T04:32:08Z |
| publishDate | 2024 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:caff57a2-cc51-4cb9-b37c-cdf86002245e2025-01-06T14:31:00ZEffects of azithromycin in severe eosinophilic asthma with concomitant monoclonal antibody treatmentJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:caff57a2-cc51-4cb9-b37c-cdf86002245eEnglishSymplectic ElementsBMJ Publishing Group2024Lavoie, GHowell, IMelhorn, JBorg, CBermejo-Sanchez, LSeymour, JJabeen, MFFries, AHynes, GPavord, IDHinks, TSCPetousi, N<p>Macrolides reduce exacerbations when added to inhaled therapy in severe asthma. However, there is little published evidence for effectiveness in patients treated with biologics. We conducted a retrospective audit of all patients who started azithromycin while on biologics in our centre. Compared to those that did not start azithromycin, these individuals had more exacerbations and a phenotype of chronic bronchitis and/or frequent purulent exacerbations. Azithromycin added-on to biologics reduced the annual rate of steroid-treated and antibiotic-treated exacerbations, improved symptom scores (ACQ5) but did not change lung function. This suggests azithromycin may be an effective treatment in patients on biologics with residual exacerbations.</p> |
| spellingShingle | Lavoie, G Howell, I Melhorn, J Borg, C Bermejo-Sanchez, L Seymour, J Jabeen, MF Fries, A Hynes, G Pavord, ID Hinks, TSC Petousi, N Effects of azithromycin in severe eosinophilic asthma with concomitant monoclonal antibody treatment |
| title | Effects of azithromycin in severe eosinophilic asthma with concomitant monoclonal antibody treatment |
| title_full | Effects of azithromycin in severe eosinophilic asthma with concomitant monoclonal antibody treatment |
| title_fullStr | Effects of azithromycin in severe eosinophilic asthma with concomitant monoclonal antibody treatment |
| title_full_unstemmed | Effects of azithromycin in severe eosinophilic asthma with concomitant monoclonal antibody treatment |
| title_short | Effects of azithromycin in severe eosinophilic asthma with concomitant monoclonal antibody treatment |
| title_sort | effects of azithromycin in severe eosinophilic asthma with concomitant monoclonal antibody treatment |
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