P387Knock-in mouse model of PRKAG2 cardiomyopathy (R299Q) exhibits altered Ca2+-dependent cardiac contractility and reduced protein kinase A activity.

Familial hypertrophic cardiomyopathy (HCM) is most commonly caused by mutations in sarcomeric proteins; however, a unifying mechanism of disease pathogenesis has yet to be identified. Beyond the sarcomere, mutations in the gene (PRKAG2) encoding the γ2 subunit of AMP-activated protein kinase (AMPK),...

Full description

Bibliographic Details
Main Authors: Turtle, C, Robinson, P, Yavari, A, Ghaffari, S, Pinter, K, Watkins, H, Redwood, C
Format: Journal article
Language:English
Published: 2014