Kinetic and structural characterization of the first B3 metallo-β-lactamase with an active-site glutamic acid

Kinetic and structural characterization of the first B3 metallo-β-lactamase with an active-site glutamic acid

The structural diversity in metallo-β-lactamases (MBLs), especially in the vicinity of the active site, has been a major hurdle in the development of clinically effective inhibitors. Representatives from three variants of the B3 MBL subclass, containing either the canonical HHH/DHH active-site motif...

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Príomhchruthaitheoirí:	Wilson, LA, Knaven, EG, Morris, MT, Monteiro Pedroso, M, Schofield, CJ, Brück, TB, Boden, M, Waite, DW, Hugenholtz, P, Guddat, L, Schenk, G
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	American Society for Microbiology 2021

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