Genetic predisposition to coronary artery disease in type 2 diabetes
Background - Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes (T2D). Methods - To test whether this reflects differential genetic influences on CAD-risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66,643 subjects...
| Үндсэн зохиолчид: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Формат: | Journal article |
| Хэл сонгох: | English |
| Хэвлэсэн: |
Lippincott, Williams & Wilkins
2020
|
| _version_ | 1826296802029076480 |
|---|---|
| author | van Zuydam, NR Ladenvall, C Voight, BF Strawbridge, RJ Fernandez Tajes, J Rayner, NW Robertson, NR Mahajan, A Vlachopoulou, E Goel, A Kleber, ME Nelson, CP Kwee, LC Esko, T Mihailov, E Mägi, R Milani, L Fischer, K Kanoni, S Kumar, J Song, C Hartiala, JA Pedersen, NL Perola, M Gieger, C Peters, A Qu, L Willems, SM Doney, ASF Morris, AD Zheng, Y Sesti, G Hu, FB Qi, L Laakso, M Thorsteinsdottir, U Grallert, H van Duijn, C Reilly, MP Ingelsson, E Deloukas, P Kathiresan, S Metspalu, A Shah, SH Sinisalo, J Salomaa, V Hamsten, A Samani, NJ März, W Hazen, SL Watkins, H |
| author_facet | van Zuydam, NR Ladenvall, C Voight, BF Strawbridge, RJ Fernandez Tajes, J Rayner, NW Robertson, NR Mahajan, A Vlachopoulou, E Goel, A Kleber, ME Nelson, CP Kwee, LC Esko, T Mihailov, E Mägi, R Milani, L Fischer, K Kanoni, S Kumar, J Song, C Hartiala, JA Pedersen, NL Perola, M Gieger, C Peters, A Qu, L Willems, SM Doney, ASF Morris, AD Zheng, Y Sesti, G Hu, FB Qi, L Laakso, M Thorsteinsdottir, U Grallert, H van Duijn, C Reilly, MP Ingelsson, E Deloukas, P Kathiresan, S Metspalu, A Shah, SH Sinisalo, J Salomaa, V Hamsten, A Samani, NJ März, W Hazen, SL Watkins, H |
| author_sort | van Zuydam, NR |
| collection | OXFORD |
| description | Background - Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes (T2D).
Methods - To test whether this reflects differential genetic influences on CAD-risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66,643 subjects (27,708 with CAD and 24,259 with T2D). Variants showing apparent association with CAD in stratified analyses and/or evidence of interaction were evaluated in a further 117,787 subjects (16,694 with CAD and 11,537 with T2D).
Results - None of the previously characterised CAD loci was found to have specific effects on CAD in T2D individuals and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background.
Conclusions - This study found no evidence that the genetic architecture of CAD differs in those with T2D compared to those without T2D.
|
| first_indexed | 2024-03-07T04:21:57Z |
| format | Journal article |
| id | oxford-uuid:cb4f611e-19ef-4770-bc47-abcdf9809997 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:21:57Z |
| publishDate | 2020 |
| publisher | Lippincott, Williams & Wilkins |
| record_format | dspace |
| spelling | oxford-uuid:cb4f611e-19ef-4770-bc47-abcdf98099972022-03-27T07:14:07ZGenetic predisposition to coronary artery disease in type 2 diabetesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cb4f611e-19ef-4770-bc47-abcdf9809997EnglishSymplectic ElementsLippincott, Williams & Wilkins 2020van Zuydam, NRLadenvall, CVoight, BFStrawbridge, RJFernandez Tajes, JRayner, NWRobertson, NRMahajan, AVlachopoulou, EGoel, AKleber, MENelson, CPKwee, LCEsko, TMihailov, EMägi, RMilani, LFischer, KKanoni, SKumar, JSong, CHartiala, JAPedersen, NLPerola, MGieger, CPeters, AQu, LWillems, SMDoney, ASFMorris, ADZheng, YSesti, GHu, FBQi, LLaakso, MThorsteinsdottir, UGrallert, Hvan Duijn, CReilly, MPIngelsson, EDeloukas, PKathiresan, SMetspalu, AShah, SHSinisalo, JSalomaa, VHamsten, ASamani, NJMärz, WHazen, SLWatkins, HBackground - Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes (T2D). Methods - To test whether this reflects differential genetic influences on CAD-risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66,643 subjects (27,708 with CAD and 24,259 with T2D). Variants showing apparent association with CAD in stratified analyses and/or evidence of interaction were evaluated in a further 117,787 subjects (16,694 with CAD and 11,537 with T2D). Results - None of the previously characterised CAD loci was found to have specific effects on CAD in T2D individuals and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background. Conclusions - This study found no evidence that the genetic architecture of CAD differs in those with T2D compared to those without T2D. |
| spellingShingle | van Zuydam, NR Ladenvall, C Voight, BF Strawbridge, RJ Fernandez Tajes, J Rayner, NW Robertson, NR Mahajan, A Vlachopoulou, E Goel, A Kleber, ME Nelson, CP Kwee, LC Esko, T Mihailov, E Mägi, R Milani, L Fischer, K Kanoni, S Kumar, J Song, C Hartiala, JA Pedersen, NL Perola, M Gieger, C Peters, A Qu, L Willems, SM Doney, ASF Morris, AD Zheng, Y Sesti, G Hu, FB Qi, L Laakso, M Thorsteinsdottir, U Grallert, H van Duijn, C Reilly, MP Ingelsson, E Deloukas, P Kathiresan, S Metspalu, A Shah, SH Sinisalo, J Salomaa, V Hamsten, A Samani, NJ März, W Hazen, SL Watkins, H Genetic predisposition to coronary artery disease in type 2 diabetes |
| title | Genetic predisposition to coronary artery disease in type 2 diabetes |
| title_full | Genetic predisposition to coronary artery disease in type 2 diabetes |
| title_fullStr | Genetic predisposition to coronary artery disease in type 2 diabetes |
| title_full_unstemmed | Genetic predisposition to coronary artery disease in type 2 diabetes |
| title_short | Genetic predisposition to coronary artery disease in type 2 diabetes |
| title_sort | genetic predisposition to coronary artery disease in type 2 diabetes |
| work_keys_str_mv | AT vanzuydamnr geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT ladenvallc geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT voightbf geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT strawbridgerj geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT fernandeztajesj geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT raynernw geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT robertsonnr geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT mahajana geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT vlachopouloue geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT goela geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT kleberme geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT nelsoncp geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT kweelc geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT eskot geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT mihailove geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT magir geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT milanil geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT fischerk geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT kanonis geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT kumarj geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT songc geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT hartialaja geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT pedersennl geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT perolam geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT giegerc geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT petersa geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT qul geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT willemssm geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT doneyasf geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT morrisad geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT zhengy geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT sestig geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT hufb geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT qil geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT laaksom geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT thorsteinsdottiru geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT grallerth geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT vanduijnc geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT reillymp geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT ingelssone geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT deloukasp geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT kathiresans geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT metspalua geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT shahsh geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT sinisaloj geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT salomaav geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT hamstena geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT samaninj geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT marzw geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT hazensl geneticpredispositiontocoronaryarterydiseaseintype2diabetes AT watkinsh geneticpredispositiontocoronaryarterydiseaseintype2diabetes |