The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: A 1H-MRS study in first-episode psychosis patients
<strong>Introduction:</strong> Glutamatergic dysfunction is implicated in the pathophysiology of schizophrenia. It is unclear whether glutamatergic dysfunction predicts response to treatment or if antipsychotic treatment influences glutamate levels. We investigated the effect of antipsyc...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Frontiers Media
2022
|
| _version_ | 1797108004417437696 |
|---|---|
| author | Zahid, U McCutcheon, RA Borgan, F Jauhar, S Pepper, F Nour, MM Rogdaki, M Osugo, M Murray, GK Hathway, P Murray, RM Howes, OD |
| author_facet | Zahid, U McCutcheon, RA Borgan, F Jauhar, S Pepper, F Nour, MM Rogdaki, M Osugo, M Murray, GK Hathway, P Murray, RM Howes, OD |
| author_sort | Zahid, U |
| collection | OXFORD |
| description | <strong>Introduction:</strong> Glutamatergic dysfunction is implicated in the pathophysiology of schizophrenia. It is unclear whether glutamatergic dysfunction predicts response to treatment or if antipsychotic treatment influences glutamate levels. We investigated the effect of antipsychotic treatment on glutamatergic levels in the anterior cingulate cortex (ACC), and whether there is a relationship between baseline glutamatergic levels and clinical response after antipsychotic treatment in people with first episode psychosis (FEP).
<br><strong>
Materials and methods: </strong>The sample comprised 25 FEP patients; 22 completed magnetic resonance spectroscopy scans at both timepoints. Symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS).
<br><strong>
Results: </strong>There was no significant change in glutamate [baseline 13.23 ± 2.33; follow-up 13.89 ± 1.74; t(21) = −1.158, p = 0.260], or Glx levels [baseline 19.64 ± 3.26; follow-up 19.66 ± 2.65; t(21) = −0.034, p = 0.973]. There was no significant association between glutamate or Glx levels at baseline and the change in PANSS positive (Glu r = 0.061, p = 0.777, Glx r = −0.152, p = 0.477), negative (Glu r = 0.144, p = 0.502, Glx r = 0.052, p = 0.811), general (Glu r = 0.110, p = 0.607, Glx r = −0.212, p = 0.320), or total scores (Glu r = 0.078, p = 0.719 Glx r = −0.155, p = 0.470).
<br><strong>
Conclusion: </strong>These findings indicate that treatment response is unlikely to be associated with baseline glutamatergic metabolites prior to antipsychotic treatment, and there is no major effect of antipsychotic treatment on glutamatergic metabolites in the ACC. |
| first_indexed | 2024-03-07T07:21:52Z |
| format | Journal article |
| id | oxford-uuid:cb6b8bae-a4ab-42a1-a4e4-17635ac7f525 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:21:52Z |
| publishDate | 2022 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:cb6b8bae-a4ab-42a1-a4e4-17635ac7f5252022-10-19T14:09:15ZThe effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: A 1H-MRS study in first-episode psychosis patientsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cb6b8bae-a4ab-42a1-a4e4-17635ac7f525EnglishSymplectic ElementsFrontiers Media2022Zahid, UMcCutcheon, RABorgan, FJauhar, SPepper, FNour, MMRogdaki, MOsugo, MMurray, GKHathway, PMurray, RMHowes, OD<strong>Introduction:</strong> Glutamatergic dysfunction is implicated in the pathophysiology of schizophrenia. It is unclear whether glutamatergic dysfunction predicts response to treatment or if antipsychotic treatment influences glutamate levels. We investigated the effect of antipsychotic treatment on glutamatergic levels in the anterior cingulate cortex (ACC), and whether there is a relationship between baseline glutamatergic levels and clinical response after antipsychotic treatment in people with first episode psychosis (FEP). <br><strong> Materials and methods: </strong>The sample comprised 25 FEP patients; 22 completed magnetic resonance spectroscopy scans at both timepoints. Symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). <br><strong> Results: </strong>There was no significant change in glutamate [baseline 13.23 ± 2.33; follow-up 13.89 ± 1.74; t(21) = −1.158, p = 0.260], or Glx levels [baseline 19.64 ± 3.26; follow-up 19.66 ± 2.65; t(21) = −0.034, p = 0.973]. There was no significant association between glutamate or Glx levels at baseline and the change in PANSS positive (Glu r = 0.061, p = 0.777, Glx r = −0.152, p = 0.477), negative (Glu r = 0.144, p = 0.502, Glx r = 0.052, p = 0.811), general (Glu r = 0.110, p = 0.607, Glx r = −0.212, p = 0.320), or total scores (Glu r = 0.078, p = 0.719 Glx r = −0.155, p = 0.470). <br><strong> Conclusion: </strong>These findings indicate that treatment response is unlikely to be associated with baseline glutamatergic metabolites prior to antipsychotic treatment, and there is no major effect of antipsychotic treatment on glutamatergic metabolites in the ACC. |
| spellingShingle | Zahid, U McCutcheon, RA Borgan, F Jauhar, S Pepper, F Nour, MM Rogdaki, M Osugo, M Murray, GK Hathway, P Murray, RM Howes, OD The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: A 1H-MRS study in first-episode psychosis patients |
| title | The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: A 1H-MRS study in first-episode psychosis patients |
| title_full | The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: A 1H-MRS study in first-episode psychosis patients |
| title_fullStr | The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: A 1H-MRS study in first-episode psychosis patients |
| title_full_unstemmed | The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: A 1H-MRS study in first-episode psychosis patients |
| title_short | The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: A 1H-MRS study in first-episode psychosis patients |
| title_sort | effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response a 1h mrs study in first episode psychosis patients |
| work_keys_str_mv | AT zahidu theeffectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT mccutcheonra theeffectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT borganf theeffectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT jauhars theeffectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT pepperf theeffectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT nourmm theeffectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT rogdakim theeffectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT osugom theeffectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT murraygk theeffectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT hathwayp theeffectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT murrayrm theeffectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT howesod theeffectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT zahidu effectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT mccutcheonra effectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT borganf effectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT jauhars effectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT pepperf effectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT nourmm effectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT rogdakim effectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT osugom effectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT murraygk effectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT hathwayp effectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT murrayrm effectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients AT howesod effectofantipsychoticsonglutamatelevelsintheanteriorcingulatecortexandclinicalresponsea1hmrsstudyinfirstepisodepsychosispatients |