In-vivo 31P-MRS of skeletal muscle and liver: A way for non-invasive assessment of their metabolism
In addition to direct assessment of high energy phosphorus containing metabolite content within tissues, phosphorus magnetic resonance spectroscopy (31P-MRS) provides options to measure phospholipid metabolites and cellular pH, as well as the kinetics of chemical reactions of energy metabolism in vi...
| Main Authors: | , , |
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| 格式: | Journal article |
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Elsevier
2017
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| _version_ | 1826296830697144320 |
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| author | Valkovič, L Chmelík, M Krššák, M |
| author_facet | Valkovič, L Chmelík, M Krššák, M |
| author_sort | Valkovič, L |
| collection | OXFORD |
| description | In addition to direct assessment of high energy phosphorus containing metabolite content within tissues, phosphorus magnetic resonance spectroscopy (31P-MRS) provides options to measure phospholipid metabolites and cellular pH, as well as the kinetics of chemical reactions of energy metabolism in vivo. Even though the great potential of 31P-MR was recognized over 30 years ago, modern MR systems, as well as new, dedicated hardware and measurement techniques provide further opportunities for research of human biochemistry. This paper presents a methodological overview of the 31P-MR techniques that can be used for basic, physiological, or clinical research of human skeletal muscle and liver in vivo. Practical issues of 31P-MRS experiments and examples of potential applications are also provided. As signal localization is essential for liver 31P-MRS and is important for dynamic muscle examinations as well, typical localization strategies for 31P-MR are also described. |
| first_indexed | 2024-03-07T04:22:23Z |
| format | Journal article |
| id | oxford-uuid:cb750154-ea9c-4c08-8fb1-5acdb2f1e90c |
| institution | University of Oxford |
| last_indexed | 2024-03-07T04:22:23Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:cb750154-ea9c-4c08-8fb1-5acdb2f1e90c2022-03-27T07:15:05ZIn-vivo 31P-MRS of skeletal muscle and liver: A way for non-invasive assessment of their metabolismJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cb750154-ea9c-4c08-8fb1-5acdb2f1e90cSymplectic Elements at OxfordElsevier2017Valkovič, LChmelík, MKrššák, MIn addition to direct assessment of high energy phosphorus containing metabolite content within tissues, phosphorus magnetic resonance spectroscopy (31P-MRS) provides options to measure phospholipid metabolites and cellular pH, as well as the kinetics of chemical reactions of energy metabolism in vivo. Even though the great potential of 31P-MR was recognized over 30 years ago, modern MR systems, as well as new, dedicated hardware and measurement techniques provide further opportunities for research of human biochemistry. This paper presents a methodological overview of the 31P-MR techniques that can be used for basic, physiological, or clinical research of human skeletal muscle and liver in vivo. Practical issues of 31P-MRS experiments and examples of potential applications are also provided. As signal localization is essential for liver 31P-MRS and is important for dynamic muscle examinations as well, typical localization strategies for 31P-MR are also described. |
| spellingShingle | Valkovič, L Chmelík, M Krššák, M In-vivo 31P-MRS of skeletal muscle and liver: A way for non-invasive assessment of their metabolism |
| title | In-vivo 31P-MRS of skeletal muscle and liver: A way for non-invasive assessment of their metabolism |
| title_full | In-vivo 31P-MRS of skeletal muscle and liver: A way for non-invasive assessment of their metabolism |
| title_fullStr | In-vivo 31P-MRS of skeletal muscle and liver: A way for non-invasive assessment of their metabolism |
| title_full_unstemmed | In-vivo 31P-MRS of skeletal muscle and liver: A way for non-invasive assessment of their metabolism |
| title_short | In-vivo 31P-MRS of skeletal muscle and liver: A way for non-invasive assessment of their metabolism |
| title_sort | in vivo 31p mrs of skeletal muscle and liver a way for non invasive assessment of their metabolism |
| work_keys_str_mv | AT valkovicl invivo31pmrsofskeletalmuscleandliverawayfornoninvasiveassessmentoftheirmetabolism AT chmelikm invivo31pmrsofskeletalmuscleandliverawayfornoninvasiveassessmentoftheirmetabolism AT krssakm invivo31pmrsofskeletalmuscleandliverawayfornoninvasiveassessmentoftheirmetabolism |