Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection.
Understanding the regulation of immune responses is central for control of autoimmune and infectious disease. In murine models of autoimmunity and chronic inflammatory disease, potent regulatory T lymphocytes have recently been characterized. Despite an explosion of interest in these cells, their re...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2005
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| _version_ | 1826296839107772416 |
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| author | Walther, M Tongren, J Andrews, L Korbel, D King, E Fletcher, H Andersen, R Bejon, P Thompson, F Dunachie, S Edele, F de Souza, J Sinden, R Gilbert, S Riley, E Hill, A |
| author_facet | Walther, M Tongren, J Andrews, L Korbel, D King, E Fletcher, H Andersen, R Bejon, P Thompson, F Dunachie, S Edele, F de Souza, J Sinden, R Gilbert, S Riley, E Hill, A |
| author_sort | Walther, M |
| collection | OXFORD |
| description | Understanding the regulation of immune responses is central for control of autoimmune and infectious disease. In murine models of autoimmunity and chronic inflammatory disease, potent regulatory T lymphocytes have recently been characterized. Despite an explosion of interest in these cells, their relevance to human disease has been uncertain. In a longitudinal study of malaria sporozoite infection via the natural route, we provide evidence that regulatory T cells have modifying effects on blood-stage infection in vivo in humans. Cells with the characteristics of regulatory T cells are rapidly induced following blood-stage infection and are associated with a burst of TGF-beta production, decreased proinflammatory cytokine production, and decreased antigen-specific immune responses. Both the production of TGF-beta and the presence of CD4+CD25+FOXP3+ regulatory T cells are associated with higher rates of parasite growth in vivo. P. falciparum-mediated induction of regulatory T cells may represent a parasite-specific virulence factor. |
| first_indexed | 2024-03-07T04:22:31Z |
| format | Journal article |
| id | oxford-uuid:cb80bfcd-e1ac-4464-9275-2265656e41e3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:22:31Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:cb80bfcd-e1ac-4464-9275-2265656e41e32022-03-27T07:15:19ZUpregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cb80bfcd-e1ac-4464-9275-2265656e41e3EnglishSymplectic Elements at Oxford2005Walther, MTongren, JAndrews, LKorbel, DKing, EFletcher, HAndersen, RBejon, PThompson, FDunachie, SEdele, Fde Souza, JSinden, RGilbert, SRiley, EHill, AUnderstanding the regulation of immune responses is central for control of autoimmune and infectious disease. In murine models of autoimmunity and chronic inflammatory disease, potent regulatory T lymphocytes have recently been characterized. Despite an explosion of interest in these cells, their relevance to human disease has been uncertain. In a longitudinal study of malaria sporozoite infection via the natural route, we provide evidence that regulatory T cells have modifying effects on blood-stage infection in vivo in humans. Cells with the characteristics of regulatory T cells are rapidly induced following blood-stage infection and are associated with a burst of TGF-beta production, decreased proinflammatory cytokine production, and decreased antigen-specific immune responses. Both the production of TGF-beta and the presence of CD4+CD25+FOXP3+ regulatory T cells are associated with higher rates of parasite growth in vivo. P. falciparum-mediated induction of regulatory T cells may represent a parasite-specific virulence factor. |
| spellingShingle | Walther, M Tongren, J Andrews, L Korbel, D King, E Fletcher, H Andersen, R Bejon, P Thompson, F Dunachie, S Edele, F de Souza, J Sinden, R Gilbert, S Riley, E Hill, A Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection. |
| title | Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection. |
| title_full | Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection. |
| title_fullStr | Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection. |
| title_full_unstemmed | Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection. |
| title_short | Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection. |
| title_sort | upregulation of tgf beta foxp3 and cd4 cd25 regulatory t cells correlates with more rapid parasite growth in human malaria infection |
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