Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.

As a result of deprivation of oxygen (hypoxia) and nutrients, the growth and viability of cells is reduced. Hypoxia-inducible factor (HIF)-1alpha helps to restore oxygen homeostasis by inducing glycolysis, erythropoiesis and angiogenesis. Here we show that hypoxia and hypoglycaemia reduce proliferat...

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Dades bibliogràfiques
Autors principals: Carmeliet, P, Dor, Y, Herbert, J, Fukumura, D, Brusselmans, K, Dewerchin, M, Neeman, M, Bono, F, Abramovitch, R, Maxwell, P, Koch, C, Ratcliffe, P, Moons, L, Jain, R, Collen, D, Keshert, E, Keshet, E
Format: Journal article
Idioma:English
Publicat: 1998

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