Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation.

Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation.

BACKGROUND: X chromosome inactivation, the mechanism used by mammals to equalise dosage of X-linked genes in XX females relative to XY males, is triggered by chromosome-wide localisation of a cis-acting non-coding RNA, Xist. The mechanism of Xist RNA spreading and Xist-dependent silencing is poorly...

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Bibliographische Detailangaben
Hauptverfasser:	Tang, Y, Huntley, D, Montana, G, Cerase, A, Nesterova, T, Brockdorff, N
Format:	Journal article
Sprache:	English
Veröffentlicht:	2010

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