Concentration-dependent mortality of chloroquine in overdose

Hydroxychloroquine and chloroquine are used extensively in malaria and rheumatological conditions, and now in COVID-19 prevention and treatment. Although generally safe they are potentially lethal in overdose. In-vitro data suggest that high concentrations and thus high doses are needed for COVID-19...

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Detalhes bibliográficos
Main Authors: Watson, JA, Tarning, J, Hoglund, RM, Baud, FJ, Megarbane, B, Clemessy, J-L, White, NJ
Formato: Journal article
Idioma:English
Publicado em: eLife Sciences Publications 2020