A panoply of errors: polymerase proofreading domain mutations in cancer
Although it has long been recognized that the exonucleolytic proofreading activity intrinsic to the replicative DNA polymerases Pol δ and Pol ε is essential for faithful replication of DNA, evidence that defective DNA polymerase proofreading contributes to human malignancy has been limited. However,...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Published: |
Nature Research
2016
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