SPINE workshop on automated X-ray analysis: a progress report.

SPINE workshop on automated X-ray analysis: a progress report.

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The Structural Proteomics In Europe (SPINE) consortium contained a workpackage to address the automated X-ray analysis of macromolecules. The aim of this workpackage was to increase the throughput of three-dimensional structures while maintaining the high quality of conventional analyses. SPINE was...

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Bibliographic Details
Main Authors: Bahar, M, Ballard, C, Cohen, S, Cowtan, K, Dodson, E, Emsley, P, Esnouf, R, Keegan, R, Lamzin, V, Langer, G, Levdikov, V, Long, F, Meier, C, Muller, A, Murshudov, G, Perrakis, A, Siebold, C, Stein, N, Turkenburg, MG, Vagin, A, Winn, M, Winter, G, Wilson, K
Format: Journal article
Language:English
Published: 2006
Description
Summary:The Structural Proteomics In Europe (SPINE) consortium contained a workpackage to address the automated X-ray analysis of macromolecules. The aim of this workpackage was to increase the throughput of three-dimensional structures while maintaining the high quality of conventional analyses. SPINE was able to bring together developers of software with users from the partner laboratories. Here, the results of a workshop organized by the consortium to evaluate software developed in the member laboratories against a set of bacterial targets are described. The major emphasis was on molecular-replacement suites, where automation was most advanced. Data processing and analysis, use of experimental phases and model construction were also addressed, albeit at a lower level.

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