Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria.
6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine. The 7th patient had taken amodiaquine alone, b...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1986
|
| _version_ | 1797095144084733952 |
|---|---|
| author | Hatton, C Peto, T Bunch, C Pasvol, G Russell, S Singer, C Edwards, G Winstanley, P |
| author_facet | Hatton, C Peto, T Bunch, C Pasvol, G Russell, S Singer, C Edwards, G Winstanley, P |
| author_sort | Hatton, C |
| collection | OXFORD |
| description | 6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine. The 7th patient had taken amodiaquine alone, but at a higher dose. A retrospective analysis suggests that the frequency of severe neutropenia complicating amodiaquine taken prophylactically may be as high as 1 in 2000. |
| first_indexed | 2024-03-07T04:23:43Z |
| format | Journal article |
| id | oxford-uuid:cbe86e63-8222-49ea-9671-6466d17930d5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:23:43Z |
| publishDate | 1986 |
| record_format | dspace |
| spelling | oxford-uuid:cbe86e63-8222-49ea-9671-6466d17930d52022-03-27T07:18:07ZFrequency of severe neutropenia associated with amodiaquine prophylaxis against malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cbe86e63-8222-49ea-9671-6466d17930d5EnglishSymplectic Elements at Oxford1986Hatton, CPeto, TBunch, CPasvol, GRussell, SSinger, CEdwards, GWinstanley, P6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine. The 7th patient had taken amodiaquine alone, but at a higher dose. A retrospective analysis suggests that the frequency of severe neutropenia complicating amodiaquine taken prophylactically may be as high as 1 in 2000. |
| spellingShingle | Hatton, C Peto, T Bunch, C Pasvol, G Russell, S Singer, C Edwards, G Winstanley, P Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. |
| title | Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. |
| title_full | Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. |
| title_fullStr | Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. |
| title_full_unstemmed | Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. |
| title_short | Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. |
| title_sort | frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria |
| work_keys_str_mv | AT hattonc frequencyofsevereneutropeniaassociatedwithamodiaquineprophylaxisagainstmalaria AT petot frequencyofsevereneutropeniaassociatedwithamodiaquineprophylaxisagainstmalaria AT bunchc frequencyofsevereneutropeniaassociatedwithamodiaquineprophylaxisagainstmalaria AT pasvolg frequencyofsevereneutropeniaassociatedwithamodiaquineprophylaxisagainstmalaria AT russells frequencyofsevereneutropeniaassociatedwithamodiaquineprophylaxisagainstmalaria AT singerc frequencyofsevereneutropeniaassociatedwithamodiaquineprophylaxisagainstmalaria AT edwardsg frequencyofsevereneutropeniaassociatedwithamodiaquineprophylaxisagainstmalaria AT winstanleyp frequencyofsevereneutropeniaassociatedwithamodiaquineprophylaxisagainstmalaria |