Protein-protein interaction site mapping using NMR-detected mutational scanning.

Protein-protein interaction site mapping using NMR-detected mutational scanning.

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We demonstrate a novel NMR method for the mapping of protein-protein interaction sites. In our approach protein-protein binding sites are mapped by competition binding experiments using indirect NMR reporter technology and Ala positional scanning. The methodology provides high sensitivity, ease of i...

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Príomhchruthaitheoirí: Baminger, B, Ludwiczek, M, Kontaxis, G, Knapp, S, Konrat, R
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2007
Ábhair:
genetics
Reproducibility of Results
Protein Interaction Mapping
Models, Molecular
TCF Transcription Factors
beta Catenin
Transcription Factor 7-Like 2 Protein
Ligands
methods
Binding, Competitive
metabolism
Nuclear Magnetic Resonance, Biomolecular
Mutation
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