The p53 response: a new mitochondrial role for cofactor strap

The p53 response: a new mitochondrial role for cofactor strap

<p>Strap is a DNA damage responsive p53 cofactor, reflecting its control by the DNA damage signalling pathway. This study identified Strap at the mitochondria where it is damage regulated and can augment p53-dependent cytochrome c release leading to apoptosis. Moreover, p53 and Strap facilitat...

Bibliografski detalji
Glavni autor:	Maniam, S
Daljnji autori:	La Thangue, N
Format:	Disertacija
Jezik:	English
Izdano:	2013
Teme:	Oncology

Slični predmeti

Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.
od: Maniam, S, i dr.
Izdano: (2015)

Cofactor strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase
od: Maniam, Sandra, i dr.
Izdano: (2015)

ATM and Chk2 kinase target the p53 cofactor Strap.
od: Adams, C, i dr.
Izdano: (2008)

The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.
od: Adams, C, i dr.
Izdano: (2012)

Nucleophosmin and p14ARF mediated regulation of p53
od: Abraham, A
Izdano: (2015)

A distinct p53 target gene set predicts for response to the selective p53–HDM2 inhibitor NVP-CGM097
od: Sébastien Jeay, i dr.
Izdano: (2015-05-01)

p53-cofactor JMY is a multifunctional actin nucleation factor.
od: Zuchero, J, i dr.
Izdano: (2009)

Mdm2 targets the p53 transcription cofactor JMY for degradation.
od: Coutts, A, i dr.
Izdano: (2007)

The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer
od: Juan Liu, i dr.
Izdano: (2023-03-01)

Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade
od: Arnab Ghosh, i dr.
Izdano: (2022-09-01)

Side-stepping the guardian of the genome: current cancer therapeutics targeting mutant p53
od: Iulianna C. Taritsa, i dr.
Izdano: (2025-01-01)

The role of p53 in hypoxia-induced apoptosis
od: Poole, R
Izdano: (2010)

LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function
od: Anbarasu Kumaraswamy, i dr.
Izdano: (2023-08-01)

A preliminary study of p53 oncogene expression in lung samples
od: Rahman, Md.Tahminur
Izdano: (2003)

Lipogenesis promotes mitochondrial fusion and maintains cancer stemness in human NSCLC
od: Zhen Liu, i dr.
Izdano: (2023-03-01)

Role of delta-like 4 in solid tumours and response to radiation therapy
od: Bham, S
Izdano: (2013)

Molecular genetic analysis in B-cell Lymphomas : a focus on the p53 pathway and p16INK4a
od: Zainuddin, Norafiza
Izdano: (2010)

A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60
od: Rahul Kumar, i dr.
Izdano: (2022-07-01)

Metastatic Pancreatic Cancer with BRAF and P53 Mutations: Case Report of Therapeutic Response to Doublet Targeted Therapy
od: Shenthol Sasankan, i dr.
Izdano: (2020-10-01)

mTORC1 promotes malignant large cell/anaplastic histology and is a targetable vulnerability in SHH-TP53 mutant medulloblastoma
od: Valentina Conti, i dr.
Izdano: (2021-12-01)

Validation of Airway Epithelial Cell TP53 Biomarker for Lung Cancer Risk
od: Daniel Craig, i dr.
Izdano: (2023-12-01)

Role of HR23B, HDAC6 and Myd88 and their interplay in response to HDAC inhibitor treatment
od: New, M
Izdano: (2014)

Expression signature based on TP53 target genes doesn't predict response to TP53-MDM2 inhibitor in wild type TP53 tumors
od: Dmitriy Sonkin
Izdano: (2015-10-01)

Effect of Strapping Straps Waste Fibers on Fresh and Hardened Properties of Concrete
od: Djebien Rachid, i dr.
Izdano: (2024-03-01)

Xanthorrhizol Induces Apoptosis Via the Up-regulation of Bax and p53 in HeLa Cells
od: Ismail, Norzila, i dr.
Izdano: (2005)

STRAP as a New Therapeutic Target for Poor Prognosis of Pancreatic Ductal Adenocarcinoma Patients Mainly Caused by TP53 Mutation
od: Shanshan Hu, i dr.
Izdano: (2020-09-01)

Sulfite Alters the Mitochondrial Network in Molybdenum Cofactor Deficiency
od: Anna-Theresa Mellis, i dr.
Izdano: (2021-01-01)

The identification and analysis of molecular biomarkers in the p53 tumour suppressor pathway that affect cancer progression in humans
od: Grawenda, A, i dr.
Izdano: (2013)

The bra-strap injury.
od: Nanchahal, J
Izdano: (2002)

Inguinal groin strap
od: Ingrid Parry, i dr.
Izdano: (2021-10-01)

Tensional steel strapping
od: 8096 British Standards Institution

Reactivity of p53 protein in canine transmissible venereal tumor Reatividade da proteína P53 no tumor venéreo transmissível canino
od: J.V. Moro, i dr.
Izdano: (2010-04-01)

Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress
od: Luca J. Delfinis, i dr.
Izdano: (2022-12-01)

Dual roles of p97 in DNA damage repair
od: Li, S
Izdano: (2021)

p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system.
od: Virginia Andreotti, i dr.
Izdano: (2011-01-01)

Colorectal cancer cells utilize autophagy to maintain mitochondrial metabolism for cell proliferation under nutrient stress
od: Samantha N. Devenport, i dr.
Izdano: (2021-07-01)

p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors
od: Eduardo Cepeda Cañedo, i dr.
Izdano: (2021-02-01)

Investigating a role for telomeric transcription in cancer
od: Dunkley, S
Izdano: (2018)

Multidimensional single-cell analysis identifies a role for CD2-CD58 interactions in clinical antitumor T cell responses
od: Gabrielle Romain, i dr.
Izdano: (2022-09-01)

Unexpected interactions between alkyl straps and pyridine ligands in sulfur-strapped porphyrin nanorings
od: Roche, C, i dr.
Izdano: (2017)