The p53 response: a new mitochondrial role for cofactor strap

The p53 response: a new mitochondrial role for cofactor strap

<p>Strap is a DNA damage responsive p53 cofactor, reflecting its control by the DNA damage signalling pathway. This study identified Strap at the mitochondria where it is damage regulated and can augment p53-dependent cytochrome c release leading to apoptosis. Moreover, p53 and Strap facilitat...

Полное описание

Библиографические подробности
Главный автор:	Maniam, S
Другие авторы:	La Thangue, N
Формат:	Диссертация
Язык:	English
Опубликовано:	2013
Предметы:	Oncology

Схожие документы

Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.
по: Maniam, S, и др.
Опубликовано: (2015)

Cofactor strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase
по: Maniam, Sandra, и др.
Опубликовано: (2015)

ATM and Chk2 kinase target the p53 cofactor Strap.
по: Adams, C, и др.
Опубликовано: (2008)

The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.
по: Adams, C, и др.
Опубликовано: (2012)

Nucleophosmin and p14ARF mediated regulation of p53
по: Abraham, A
Опубликовано: (2015)

A distinct p53 target gene set predicts for response to the selective p53–HDM2 inhibitor NVP-CGM097
по: Sébastien Jeay, и др.
Опубликовано: (2015-05-01)

p53-cofactor JMY is a multifunctional actin nucleation factor.
по: Zuchero, J, и др.
Опубликовано: (2009)

Mdm2 targets the p53 transcription cofactor JMY for degradation.
по: Coutts, A, и др.
Опубликовано: (2007)

The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer
по: Juan Liu, и др.
Опубликовано: (2023-03-01)

Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade
по: Arnab Ghosh, и др.
Опубликовано: (2022-09-01)

Side-stepping the guardian of the genome: current cancer therapeutics targeting mutant p53
по: Iulianna C. Taritsa, и др.
Опубликовано: (2025-01-01)

The role of p53 in hypoxia-induced apoptosis
по: Poole, R
Опубликовано: (2010)

LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function
по: Anbarasu Kumaraswamy, и др.
Опубликовано: (2023-08-01)

A preliminary study of p53 oncogene expression in lung samples
по: Rahman, Md.Tahminur
Опубликовано: (2003)

Lipogenesis promotes mitochondrial fusion and maintains cancer stemness in human NSCLC
по: Zhen Liu, и др.
Опубликовано: (2023-03-01)

Role of delta-like 4 in solid tumours and response to radiation therapy
по: Bham, S
Опубликовано: (2013)

Molecular genetic analysis in B-cell Lymphomas : a focus on the p53 pathway and p16INK4a
по: Zainuddin, Norafiza
Опубликовано: (2010)

A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60
по: Rahul Kumar, и др.
Опубликовано: (2022-07-01)

Metastatic Pancreatic Cancer with BRAF and P53 Mutations: Case Report of Therapeutic Response to Doublet Targeted Therapy
по: Shenthol Sasankan, и др.
Опубликовано: (2020-10-01)

mTORC1 promotes malignant large cell/anaplastic histology and is a targetable vulnerability in SHH-TP53 mutant medulloblastoma
по: Valentina Conti, и др.
Опубликовано: (2021-12-01)

Validation of Airway Epithelial Cell TP53 Biomarker for Lung Cancer Risk
по: Daniel Craig, и др.
Опубликовано: (2023-12-01)

Role of HR23B, HDAC6 and Myd88 and their interplay in response to HDAC inhibitor treatment
по: New, M
Опубликовано: (2014)

Expression signature based on TP53 target genes doesn't predict response to TP53-MDM2 inhibitor in wild type TP53 tumors
по: Dmitriy Sonkin
Опубликовано: (2015-10-01)

Effect of Strapping Straps Waste Fibers on Fresh and Hardened Properties of Concrete
по: Djebien Rachid, и др.
Опубликовано: (2024-03-01)

Xanthorrhizol Induces Apoptosis Via the Up-regulation of Bax and p53 in HeLa Cells
по: Ismail, Norzila, и др.
Опубликовано: (2005)

STRAP as a New Therapeutic Target for Poor Prognosis of Pancreatic Ductal Adenocarcinoma Patients Mainly Caused by TP53 Mutation
по: Shanshan Hu, и др.
Опубликовано: (2020-09-01)

Sulfite Alters the Mitochondrial Network in Molybdenum Cofactor Deficiency
по: Anna-Theresa Mellis, и др.
Опубликовано: (2021-01-01)

The identification and analysis of molecular biomarkers in the p53 tumour suppressor pathway that affect cancer progression in humans
по: Grawenda, A, и др.
Опубликовано: (2013)

The bra-strap injury.
по: Nanchahal, J
Опубликовано: (2002)

Inguinal groin strap
по: Ingrid Parry, и др.
Опубликовано: (2021-10-01)

Tensional steel strapping
по: 8096 British Standards Institution

Reactivity of p53 protein in canine transmissible venereal tumor Reatividade da proteína P53 no tumor venéreo transmissível canino
по: J.V. Moro, и др.
Опубликовано: (2010-04-01)

Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress
по: Luca J. Delfinis, и др.
Опубликовано: (2022-12-01)

Dual roles of p97 in DNA damage repair
по: Li, S
Опубликовано: (2021)

p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system.
по: Virginia Andreotti, и др.
Опубликовано: (2011-01-01)

Colorectal cancer cells utilize autophagy to maintain mitochondrial metabolism for cell proliferation under nutrient stress
по: Samantha N. Devenport, и др.
Опубликовано: (2021-07-01)

p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors
по: Eduardo Cepeda Cañedo, и др.
Опубликовано: (2021-02-01)

Investigating a role for telomeric transcription in cancer
по: Dunkley, S
Опубликовано: (2018)

Multidimensional single-cell analysis identifies a role for CD2-CD58 interactions in clinical antitumor T cell responses
по: Gabrielle Romain, и др.
Опубликовано: (2022-09-01)

Unexpected interactions between alkyl straps and pyridine ligands in sulfur-strapped porphyrin nanorings
по: Roche, C, и др.
Опубликовано: (2017)