Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.

Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.

Mutations in the CEBPA gene are present in 7%-10% of human patients with acute myeloid leukemia (AML). However, no genetic models exist that demonstrate their etiological relevance. To mimic the most common mutations affecting CEBPA-that is, those leading to loss of the 42 kDa C/EBPalpha isoform (p4...

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Bibliographic Details
Main Authors: Kirstetter, P, Schuster, M, Bereshchenko, O, Moore, S, Dvinge, H, Kurz, E, Theilgaard-Mönch, K, Månsson, R, Pedersen, T, Pabst, T, Schrock, E, Porse, B, Jacobsen, SE, Bertone, P, Tenen, D, Nerlov, C
Format: Journal article
Language:English
Published: 2008

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