Increased global transcription activity as a mechanism of replication stress in cancer
Cancer is a disease associated with genomic instability that often results from oncogene activation. This in turn leads to hyperproliferation and replication stress. However, the molecular mechanisms that underlie oncogene-induced replication stress are still poorly understood. Oncogenes such as HRA...
Main Authors: | Kotsantis, P, Silva, L, Irmscher, S, Jones, R, Folkes, L, Gromak, N, Petermann, E |
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פורמט: | Journal article |
שפה: | English |
יצא לאור: |
Nature Publishing Group
2016
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